白藜三醇对猪急性闭塞冠状动脉侧支循环的影响  

Resveratrol improves coronary collateral circulation in pigs with experimental acute coronary occlusion

作　　者：王志荣[1] 徐晤[1] 张超群[1] 谢伟[1] 周召峰[1] 周晓峰[1] 张卓琦[1] 

机构地区：[1]徐州医学院附属医院心内科,221002

出　　处：《中华心血管病杂志》2011年第10期946-949,共4页Chinese Journal of Cardiology

基　　金：江苏省卫生厅医学重点人才基金（RC2007089）;江苏省高校自然科学基金面上项目（08KJB320015）

摘　　要：目的应用冠状动脉内多普勒超声评价白藜三醇对急性闭塞冠状动脉侧支循环的影响。方法将18头健康家猪随机分为3组：白藜三醇组、硝酸甘油组和对照组。通过闭胸法建立急性冠状动脉左回旋支（LCX）闭塞的动物模型，应用冠状动脉内多普勒超声测量LCX正常状态、急性闭塞后及药物干预后相关的血流频谱。结果在冠状动脉闭塞即刻，闭塞血管远端血流平均峰值流速（APV）明显低于正常水平[（0．85±0．25）cm／s比（24．83±3．43）cm／s，P〈0．05]，持续观察印min，较闭塞即刻增加不明显[（0．83±0．24）cms比（0．85±0．25）cm／s，P〉0．05]；白藜三醇组及硝酸甘油组给药后，闭塞血管远端血流呈反向或双向，APV的绝对值[分别为（9．22±0．80）cm／s和（8．93±1．28）cm／s]明显高于闭塞即刻[分别为（0．84±0．21）cm／s和（0．86±0．26）cm／s]及对照组[（0．86±0．22）cm／s]（P均〈0．05），达峰值后数据绝对值逐渐减小，重复给药后数值再次增加；但2个给药组间比较差异无统计学意义；而白藜三醇组APV增高持续时间明显长于硝酸甘油组[2次给药总时间分别为（58．83±6．15）min比（21．80±5．79）min，P〈0．05]。结论猪急性闭塞冠状动脉自身侧支循环建立明显不足。白藜三醇能够显著促进猪急性闭塞冠状动脉侧支循环的开放，且维持时间长于硝酸甘油。Objective To evaluate the impact of resveratrol on coronary collateral circulation in pigs suffered from experimental acute coronary occlusion. Methods Eighteen healthy pigs were randomly divided into 3 groups： resveratrol group, nitroglycerin group and control group. Animal model of acute coronary occlusion was established through PTCA method, and the blood flow spectrum in the left circumflex artery （LCX） was detected using intracoronary Doppler ultrasound. Restflts The average peak velocity （APV） in infarction correlation artery （IRA） was significantly decreased immediately after coronary occlusion [ （0. 85 ± 0. 25 ） cm/s vs. （ 24. 83 ± 3.43 ） cm/s, P 〈 0. 05 ]. The APV remained unchanged during 0, 30 and 60 minutes after the occlusion. Reversed or bidirectional blood flow was observed and the APV increased significantly [ （9. 22±0. 80）ern/s vs. （0. 84 ±0. 21）cm/s, （8.93 ±1.28） cm/s vs. （0. 86 ±0. 26） cm/s respectively, P 〈 0. 05 ] after the coronary injection of resveratrol （2 mg） or nitroglycerin （0. 3 mg）. There was no significant difference in peak APV between the resveratrol and nitroglycerin groups. The duration of increased APV was significantly longer in resveratrol group than that in nitroglycerin group [ （58. 83 ± 6. 15 ） min vs. （21.80± 5.79 ） min, P 〈 0. 05 ] . Conclusions The collateral circulation after acute coronary occlusion was obviously insufficient in pigs. Resveratrol could significantly improve the blood flow in coronary collateral circulation after acute occlusion in this model.

关 键 词：心肌梗死 超声检查 多普勒 侧支循环 雌激素类 

分 类 号：R285[医药卫生—中药学]