Coexisting ankylosing spondylitis and rheumatoid arthritis： A case report with literature review  

作　　者：GUO Ying-ying YANG Li-li CUI Hua-dong ZHAO Shuai ZHANG Ning 

机构地区：[1]Department of Rheumatology and Immunology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China

出　　处：《Chinese Medical Journal》2011年第20期3430-3432,共3页中华医学杂志（英文版）

摘　　要：A 30-year-old female patient with coexisting ankylosing spondylitis and rheumatoid arthritis was diagnosed and treated. The human leukocyte antigen （HLA）-B27 is a predisposing factor of ankylosing spondylitis and HLA-DR4 is a predisposing factor of rheumatoid arthritis. This patient was HLA-B27 and HLA-DR4 positive, and ankylosing spondylitis manifested before rheumatoid arthritis. After disease modifying anti-rheumatic drugs successfully arrested ankylosing spondylitis activity the patient conceived and delivered a healthy baby. One year later, she developed peripheral polyarthritis and was diagnosed with rheumatoid arthritis. We hypothesized that pregnancy may be one of the environmental factors that can activate rheumatoid arthritis, and that disease modifying anti-rheumatic drugs play an important role in keeping the disease under control.A 30-year-old female patient with coexisting ankylosing spondylitis and rheumatoid arthritis was diagnosed and treated. The human leukocyte antigen （HLA）-B27 is a predisposing factor of ankylosing spondylitis and HLA-DR4 is a predisposing factor of rheumatoid arthritis. This patient was HLA-B27 and HLA-DR4 positive, and ankylosing spondylitis manifested before rheumatoid arthritis. After disease modifying anti-rheumatic drugs successfully arrested ankylosing spondylitis activity the patient conceived and delivered a healthy baby. One year later, she developed peripheral polyarthritis and was diagnosed with rheumatoid arthritis. We hypothesized that pregnancy may be one of the environmental factors that can activate rheumatoid arthritis, and that disease modifying anti-rheumatic drugs play an important role in keeping the disease under control.

关 键 词：ankylosing spondylitis disease modifying anti-rheumatic drugs rheumatoid arthritis 

分 类 号：TP391.41[自动化与计算机技术—计算机应用技术] TQ460.72[自动化与计算机技术—计算机科学与技术]