芽胞杆菌的表层蛋白研究及应用前景  

Progress and perspectives of surface layer proteins from Bacillus species—A review

作　　者：杨玲玲[1] 胡晓敏[1] 袁志明[1] 

机构地区：[1]中国科学院武汉病毒研究所,武汉430071

出　　处：《微生物学报》2011年第11期1440-1446,共7页Acta Microbiologica Sinica

基　　金：国家"973项目"(O403042A01)~~

摘　　要：细菌表层蛋白(surface layer protein,S-层蛋白)是由同种蛋白质或糖蛋白亚基装配而成,广泛分布于各种古生菌和真细菌表面,形成的多孔网状结构。成熟的S-层蛋白一般具有两个功能域———特异性锚定区域和自组装区域。近年来基于芽胞杆菌属几种细菌的S-层蛋白的研究已经成为热点,其在生物传感器、疫苗研制、表面展示、纳米材料、生物治理等方面具有广泛的应用前景。本文就芽胞杆菌S-层蛋白的结构,生化遗传,功能,病源相关性及其在工业和生物医学上的应用进行综述。S-layer proteins are crystalline arrays composed of numerous identical protein or glycoprotein subunits.They comprise the outermost cell envelope component in most archaea and many bacteria.The remarkable properties of S-layer proteins are their capability to self-assemble and specific binding,which give S-layer proteins a wide application potential in nanotechnology and biomimetics.Recently most study in this field was concerned on the S-layer proteins of Bacillus species.This review provided a brief survey of the current state of the study about the genetics,function,properties,pathogenic correlation and application of the S-layer proteins of Bacillus species.The aim of this review was to gain more knowledge about the function of S-layers and lead to the development of new types of surface display system and recombinant vaccines,diagnostic agents and biocompatible surfaces.

关 键 词：S-层蛋白 自组装 锚定 芽胞杆菌 纳米生物技术 

分 类 号：Q93[生物学—微生物学]