SLC30A8基因rs13266634位点C／T多态性与1型糖尿病易患性的关系——病例对照研究及meta分析  

Association of SLC30A8 gene rs13266634 C/T polymorphism with type 1 diabetes ： case-control study and meta-analysis

作　　者：钱莉[1] 徐宽枫[1] 刘璇[1] 单珊[1] 杨涛[1] 

机构地区：[1]南京医科大学第一附属医院内分泌科,210029

出　　处：《中华糖尿病杂志》2011年第5期376-379,共4页CHINESE JOURNAL OF DIABETES MELLITUS

摘　　要：目的评价SLC30A8基因rs13266634位点C／T多态性与1型糖尿病的关系。方法选取2008年9月至2010年11月就诊于江苏省人民医院及其25家合作单位的351例1型糖尿病患者（糖尿病组），其中男183例，女168例，平均年龄（20±11）岁。同期于江苏省人民医院体检中心选取429名健康志愿者（健康对照组），其中男201例，女228例，平均年龄（23±4）岁。所有研究对象均行SLC30A8基因rs13266634位点C／T多态性分析。检索Pubmed及中文期刊CNKI数据库，入选有关SLC30A8基因rs13266634位点多态性与1型糖尿病的病例对照研究，进行meta分析。结果病例对照研究表明，糖尿病组与健康对照组SLC30A8rs13266634基因分布频率无显著差异[比值比（OR）为0．96，95％可信区间（95％ CI）=0．79～1．18，P=0．71]。共有5篇文献纳入nleta分析，其中1型糖尿病患者10646例，健康对照者10242名。2组异质性检验，2为0％，异质性检验P值为0．595，无显著异质性，故采用固定效应模型进行数据合并。纳入研究的合并OR值为1．02，95％C／为0．98～1．06，P值为0．38。Begg’s检验中P值为0．155，即纳入研究无发表偏倚。结论病例对照研究及meta分析结果均表明SLC30A8基因rs13266634位点C／T多态性与1型糖尿病易患性无显著关联。Objective To evaluate the relationship between SLC30A8 gene rs13266634 C/T polymorphism and type 1 diabetes mellitus （T1DM）. Methods A total of 351 T1 DM patients and 429 healthy subjects were enrolled in this case-control study from September 2008 to November 2010. The TI DM group included 183 males and 168 females, aged （20 ± 11 ） years; and the control group included 201 males and 228 females, aged （ 23 ± 4 ） years. All the participants underwent genotyping of the SLC30A8 gene rs13266634 polymorphism. In addition, systematic review and recta-analysis of the publishing literature on genetic association of SLC30A8 rs13266634 polymorphism and T1DM were performed in Pubmed and CNKI. Results Our case-control study showed that rs13266634 C/T polymorphism was not associated with TI DM （odds ratio =0. 96, 95% confidence interval （95% CI） =0. 79 to 1.18, P =0. 71 ）. The literature search identified 5 studies that analyzed the association of the SLC30A8 gene rs13266634 polymorphism with T1DM, including 10 646 TIDM patients and 10 207 healthy controls. Since I^2 = 0% and Pheterogeneity = 0. 595, all the studies were combined with fixed effects model. Odds ratios of C allele to T allele was 1.02 （95% CI： 0. 98 to 1.06, P =0. 38） , and Begg＇ s test revealed no significant publication bias. Conclusion Our results indicate that SLC30A8 gene rs13266634 polymorphism is not associated with increased risk of TI DM.

关 键 词：糖尿病 1型 基因多态性 SLC30A8基因 META分析 

分 类 号：R587.1[医药卫生—内分泌]