老年高血压病患者尿转铁蛋白/肌酐的相关因素研究  

Associated Factors of Urine Transferrin-to-Creatinine Ratio in Elderly Hypertensive Patients

作　　者：边平达[1] 王珏[1] 李秀央[2] 

机构地区：[1]浙江省人民医院望江山院区,杭州310024 [2]浙江大学流行病与卫生统计学教研室,杭州310031

出　　处：《中国中西医结合肾病杂志》2011年第10期883-885,共3页Chinese Journal of Integrated Traditional and Western Nephrology

基　　金：浙江省医药卫生科学研究基金资助项目(No.2010KYB009)

摘　　要：目的:通过筛选老年高血压病(EH)患者尿转铁蛋白/肌酐(TRF/Cr)的相关因素,来寻找减少老年EH患者尿转铁蛋白(TRF)排出的方法。方法:对1058例老年EH患者进行24h动态血压检测、实验室检查、尿TRF和肌酐(Cr)检测,运用Logistic回归分析方法筛选老年EH患者尿TRF/Cr的独立相关因素。结果:老年EH患者尿TRF/Cr的独立相关因素有24hSBP(β=0.029,P=0.007)、高血压病程(β=0.017,P=0.012)、低密度脂蛋白胆固醇(β=0.347,P=0.047)。结论:积极防治高血压病,并降低老年EH患者的低密度脂蛋白胆固醇水平,可能是减少老年EH患者TRF排出的重要方法。Objective：To probe into the ways to reduce transferrin（TRF） by means of analysing associated factors of urine transferrin-to-creatinine ratio（TRF/Cr） in elderly patients with essential hypertension（EH）.Methods：A Cross-sectional survey was conducted comprising a sample of 1058 elderly hypertensive patients（men：women,844：214;mean age,79±4 years old）.All patients underwent 24 h ambulatory blood pressure monitoring,laboratory measurement,urine TRF and Cr measurement.Univariate analyses and Logistic analyses were applied to discover independent associated factors of TRF/Cr.Results：The finding of the study showed that independent associated factors of TRF/Cr included 24 h SBP（β=0.029,P=0.007）,the course of EH（β=0.017,P=0.012）,low-density lipoprotein cholesterol（LDL-C,β=0.347,P =0.047）.Conclusion：The probable ways to reduce TRF in elderly hypertensive patients are both to take effective measures to prevention and cure of EH,and to decrease the concentration of blood LDL-C.

关 键 词：转铁蛋白 高血压病 

分 类 号：R544.1[医药卫生—心血管疾病]