头孢他啶连续与间断给药方式治疗兔肺炎血清杀菌活性的研究  

Serum Bactericidal Activity of Ceftazidime:Continuous Infusion Versus Intermittent Infusion in A Klebsiella Pneumoniae Rabbit Pneumonia Model

作　　者：佟淑平[1] 王琪[2] 胡秀娟[3] 王慧玲[2] 王莺燕[4] 王涛[5] 

机构地区：[1]内蒙古民族大学附属医院呼吸内科,内蒙古通辽市028000 [2]大连医科大学附属二院呼吸内科 [3]天津胸科医院 [4]大连医科大学诊断学实验中心 [5]大连大学附属中山医院

出　　处：《实用心脑肺血管病杂志》2011年第12期2115-2118,共4页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：大连科技局自然科学基金资助项目(2003B3NS221)

摘　　要：目的评价头孢他啶连续与间断两种给药方式治疗兔肺炎的体内血清杀菌活性(SBA)。方法将30只雌性新西兰白兔随机分为实验组与对照组,实验组又分为高、低剂量两个亚组,感染24h后采取连续与间断两种给药方式静脉注入头孢他啶,疗程为4d;对照组不予治疗。于不同时间采集血清标本,测定不同给药方式的血清抑菌活性(SBS)及SBA。间断进行肺灌洗,绘制杀菌曲线。治疗前后分别对动物行X线检查;疗程结束后处死动物,行肺部病理检查。结果连续与间断两种给药方式的SBS、SBA各具特点。连续给药的SBS、SBA范围集中,抗菌活性稳定且持续时间长,间断给药的SBS、SBA范围分散,峰时与谷时波动较大,但两种方式高剂量组的抗菌活性均比低剂量组明显升高。杀菌曲线显示实验组的细菌数量比对照组明显降低,且连续给药方式下降更平稳。X线及病理检查显示两种给药方式的疗效相似。结论与间断给药方式相比,连续滴注头孢他啶具有SBA稳定,维持时间长等优点,提高给药剂量效果更佳。Objective To evaluate Serum Bactericidal Activity（SBA）of ceftazidime administered in continuous versus intermittent infusion in vivo.Methods 30 rabbits of Klebsiella pneumoniae pneumonia model were divided into experiment group and control group randomly.The rabbits of experiment group were given ceftazidime by continuous or intermittent infusion stochastically 24 hours after infection for 4 days.Each infusion group was divided into high-dose and low-dose sub groups.The rabbits of control group were fed as usual without giving drug.Blood samples were collected at different times after the start of drug administration.Serum bactericidal activity was determined by microdilution method.Bronchoalv eolar lavage（BAL）samples were extracted and bactericidal curve was drawn.The chest X-ray and lung pathologic examination were made before and after the treatment.Results Ceftazidime showed good antimicrobial activities in both continuous and intermittent infusion regimens.However,the characteristics of them were difference.For the continuous infusion regimen,the SBS and SBA were steady and constantly.For the intermittent infusion regimen,the SBS and SBA were unstable with the tpeak and trough level fluctuating greatly.However,the SBS and SBA of high-dose groups in the two regimens were shown to be slightly stronger than that of low-dose group.Bactericidal curve indicated that the quantities of bacteria were decreased steadily in continuous infusion regimen compared with that in intermittent infusion regimen.Of the chest X-ray examination and Lung pathologic examination are both consistent with the SBS and SBA.Conclusion In comparison,for ceftazidime,continuous infusion regimen is superior to intermittent infusion regimen for its steady and constantly SBS and SBA.It will become even better if increase the dose of the drug to some extent.

关 键 词：头孢他啶 血液杀菌作用 肺炎 

分 类 号：R332[医药卫生—人体生理学]