荷瘤鼠活体成像研究进展  

Development of Living Tumor-bearing Mice Imaging Technology

作　　者：程凯[1] 张杰[1] 

机构地区：[1]武汉大学人民医院,武汉430060

出　　处：《医学综述》2011年第21期3318-3321,共4页Medical Recapitulate

摘　　要：随着荷瘤鼠活体成像技术的发展,非侵袭性成像在临床前研究中发挥了越来越重要的作用。活体成像可以在微创或无创的条件下对活体组织或动物体内的生理生物活动进行成像跟踪。直观灵敏地检测基因的表达模式、标记和示踪细胞、探讨蛋白质间的相互作用。在此围绕可见光成像、核素成像、磁共振成像、计算机断层摄影和超声成像等5种活体成像技术,总结其特点及主要应用,并讨论活体成像技术的发展趋势。With the development of living tumor-bearing imaging technology,non-invasive imaging has gained increasing importance in pre-clinical research,which can take images of biological process in living tissues or animals in vivo This technique can monitor gene expression,trace cells and identify the interaction between proteins.5 kinds of living tumor-bearing mice imaging technology,including optical imaging,PET/SPECT,MRI,CT and ultrasound imaging,were reviewed from the aspects of their characteristics and main applications.The trends of living tumor-bearing mice imaging technology were discussed as well.

关 键 词：荷瘤鼠 活体 成像技术 荧光素酶 

分 类 号：Q334[生物学—遗传学]