常规剂量氯雷他定对皮肤斑贴试验反应程度的影响  

Influences of routine-dose Ioratadine on the intensity of patch test reaction

作　　者：黎平[1] 孙晓东[1] 施辛[1] 蔡永莲[1] 张静[1] 陈小建[1] 陈玲玲[1] 谢立夏[1] 

机构地区：[1]苏州大学附属第二医院皮肤科,215004

出　　处：《中华皮肤科杂志》2011年第11期765-767,共3页Chinese Journal of Dermatology

摘　　要：目的 探讨常规剂量氯雷他定对硫酸镍阳性皮肤斑贴试验的影响。方法 采用随机、双盲、对照方法，121例斑贴试验硫酸镍阳性的患者分为两组，试验组61例口服氯雷他定片10 mg，每日1次，连续14 d；对照组60例口服安慰剂1片，每日1次，连续14 d。在服药第11天进行斑贴试验，在服药第14天判读斑贴试验结果。结果 试验组有55例、对照组有53例患者斑贴试验反应程度没有改变，两组结果差异无统计学意义。结论 常规剂量氯雷他定对硫酸镍阳性皮肤斑贴试验反应程度没有抑制作用。Objective To investigate the influences of routine-dose loratadine on the positive patch test reaction to nickel sulfate. Methods A double-blind, controlled and randomized study was carried out. A total of 121 patients with a positive patch test reaction to nickel sulfate were divided into two groups to receive loratadine 10 mg （experimental group, n = 61） or placebo （control group, n = 60） once daily for 14 days. The patch testing of nickel sulfate was performed on day 11, and clinical evaluation of the test was carried out on day 14 after the start of treatment. The intention to treat population was used for data analysis. Results No changes were observed in the intensity of patch test reaction to nickel sulfate in 55 patients in the experimental group or 53 patients in the control group, and there was no significant difference between the two groups in the percentage of patients showing changes in the intensity of patch test reaction （9.8% vs. 11.7%, χ^2 = 0.11, P 〉 0.05）. Conclusion The routine-dose loratadine has no inhibitory effect on the intensity of skin patch test reaction to nickel sulfate.

关 键 词：镍 皮肤刺激试验 氯雷他定 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]