多项指标联合检测对诊断冠心病的价值  

Value of combined multiple index in diagnosis of coronary heart disease

作　　者：张莹莹[1] 于波[1] 李丽丽[1] 

机构地区：[1]哈尔滨医科大学附属第二医院心内科,黑龙江哈尔滨150081

出　　处：《哈尔滨医科大学学报》2011年第5期479-481,共3页Journal of Harbin Medical University

基　　金：黑龙江省博士后资助基金(LRB09-384)

摘　　要：目的探讨超敏C反应蛋白(high-sensitivity C-reactive protein,Hs-CRP)、血清半胱氨酸(homo-cysteine,Hcy)和低密度脂蛋白/高密度脂蛋白比值(low-density lipoprotein cholesterol/high-density lipopro-tein cholesterol ratio,LDL-C/HDL-C)联合检测对冠状动脉粥样硬化性心脏病(coronary heart disease,CHD)的诊断价值。方法选取2008年7月～2010年12月入院接受冠状动脉造影术检查患者264例,冠心病组165例,对照组(冠脉造影正常)99例,分别测定各组血清中Hs-CRP、Hcy和LDL-C/HDL-C的水平。结果冠心病组Hs-CRP、Hcy的含量和LDL-C/HDL-C比值均显著高于对照组(P<0.01)。联合应用Hs-CRP、Hcy和LDL-C/LDL-C对冠心病的诊断敏感度(94.5%)高于分别单独应用Hs-CRP(85.6%)、Hcy(82.3%)和TC/HDL-C(76.2%)的诊断敏感度(P<0.05)。结论联合应用Hs-CRP、Hcy和LDL-C/HDL-C更有助于冠心病的早期诊断。Objective To study the value of integrated detection of serum high-sensitivity C-reactive protein（Hs-CRP）,homocysteine（Hcy）and low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio（LDL-C/HDL-C）in diagnosis of coronary heart disease（CHD）.Methods Hs-CRP,Hcy and LDL-C/HDL-C ratio were analyzed in 165 cases of patient（CHD group） and 99 cases of control（control group）which were enrolled by coronary angiography.Results The concentration of Hs-CRP,Hcy and LDL-C/HDL-C ratio were significantly higher in CHD patients than those in control group（P0.01）.The sensitivity of integrated detection of all the three markers（92.8%） was higher than the single marker detection of either Hs-CRP（83.7%）,Hcy（80.0%）or LDL-C/HDL-C（73.4%）,P0.05.Conclusion Integrated detection of Hs-CRP,Hcy and LDL-C/HDL-C is more accurate and reliable in the diagnosis of CHD.

关 键 词：超敏C反应蛋白 血清半胱氨酸 低密度脂蛋白/高密度脂蛋白比值 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病]