骨代谢标志物与维持性血透患者全段甲状旁腺激素水平的相关性  

The correlation between the marker of bone metabolism and intact parathyroid hormone in patients undergoing maintenance hemodialysis

作　　者：王志国[1] 张家明[1] 周竞[1] 

机构地区：[1]江苏省中西医结合医院检验科,南京市210028

出　　处：《江苏医药》2011年第20期2391-2392,共2页Jiangsu Medical Journal

摘　　要：目的探讨骨代谢标志物Ⅰ型前胶原氨基端延长肽(P1NP)、β胶原特殊序列(β-Crosslaps)与维持性血透(MHD)患者全段甲状旁腺激素(iPTH)水平的相关性。方法化学发光法检测96例MHD患者iPTH水平,并以此分为高iPTH水平组(>300ng/L,A组,40例),中iPTH水平组(150～300ng/L,B组,26例)和低iPTH水平组(<150ng/L,C组,30例)。同时测定各组P1NP和β-Crosslaps水平。结果 A组P1NP和β-Crosslaps水平明显高于B、C组(P<0.05)。P1NP、β-Crosslaps与iPTH均呈明显正相关。结论 MHD患者血清P1NP、β-Crosslaps水平与肾性骨病(RBD)存在密切的相关性,可作为RBD早期诊断的指标。Objective To study the correlation between procollagen 1 N-terminal peptide（P1NP,the marker of bone metabolism） and β-Crosslaps and intact parathyroid hormone（iPTH） in patients undergoing maintenance hemodialysis（MHD）.Methods Serum iPTH was detected by chemiluminescence in 96 MHD patients,who were divided into three groups of A（iPTH 〉300 ng/L,40 cases）,B（iPTH 150-300 ng/L,26 cases） and C（iPTH〈150 ng/L,30 cases）.P1NP and β-Crosslaps were determined as well.Results Serum levels of P1NP and β-Crosslaps were higher than those of groups of B and C（P〈0.05）,which were positively correlated to iPTH.Conclusion Serum levels of P1NP and β-Crosslaps are closely correlated to renal bone disease and can be taken as the markers for early diagnosis of renal bone disease.

关 键 词：维持性血液透析 肾性骨病 Ⅰ型前胶原氨基端延长肽 β胶原特殊序列 甲状旁腺激素 

分 类 号：R589[医药卫生—内分泌]