阿藿烯对大鼠抗血栓活性作用研究  

Inhibitory effect of ajoene on thrombosis in rats

作　　者：李晓天[1] 范媛媛[1] 石迎迎[1] 

机构地区：[1]郑州大学药学院

出　　处：《中国临床药理学与治疗学》2011年第10期1086-1089,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的:研究阿藿烯对大鼠血栓形成和凝血功能的影响,评价其抗血栓活性。方法:将SD大鼠随机分为空白对照组、血塞通阳性药组(50mg/kg)、阿藿烯低剂量组(25mg/kg)、中剂量组(50mg/kg)、高剂量组(75mg/kg),各组动物连续灌胃5d,末次给药2h后建立下腔静脉结扎模型、FeCl3致动脉血栓模型、断尾流血时间测定模型测定阿藿烯对血栓形成和凝血的影响;并测定各组大鼠给药前及给药后2h血浆凝血酶原时间(PT)、活化部分凝血酶时间(APTT)。结果:阿藿烯能抑制动静脉血栓的形成,使血栓重量降低,且高剂量阿霍烯对动静脉血栓形成的抑制率均大于40%;同时有效延长大鼠断尾流血时间,并能使大鼠血浆APTT、PT明显延长(P<0.05),且都具有剂量依赖关系。结论:阿藿烯有抗血栓活性。AIM：To study the effect of ajoene on thrombosis in rats. METHODS：SD rats were randomly divided into five groups according to body weight：normal control group,Panax notoginseng Saponins group（50 mg/kg）,and ajoene groups（25,50,75 mg/kg）.Rats were given drugs everyday for 5 days,2 h after the last administration using model of ligation of the inferior vena cava,FeCl3 induced thrombosis and cuticle bleeding time to text the antithrombotic effect.Meanwhile collect blood plasma to text pronthrombin time（PT）,thromboplastin time（APTT）. RESULTS：Ajoene could inhibit the formation of arterial and venous thrombosis,and inhibition rates of high dose ajoene on thrombosis of the arteriovenous were more than 40%.And it also could significantly increase the cuticle bleeding time,prolong the levels of PT,APTT（P0.05）. CONCLUSION：Ajoene can inhibit experimental arterial and vein thrombosis.And it has the satisfactory effect on anti-thrombosis.

关 键 词：阿藿烯 抗血栓 凝血酶原时间 活化部分凝血酶时间 大鼠 

分 类 号：R965.2[医药卫生—药理学]