益气健脾中药联合马来酸依那普利片对慢性心力衰竭患者血清尿酸水平及心功能的影响  

Effect of traditional Chinese medicine combined with enalapril on uric acid levels and cardiac function in patients with in chronic heart failure

作　　者：张淑哲[1] 王仲[2] 石雪丽[2] 胡秀青[3] 商永[2] 

机构地区：[1]河北省保定市第三中心医院中医科,河北保定071051 [2]河北省保定市第三中心医院内一科,河北保定071051 [3]河北省保定市第三中心医院超声科,河北保定071051

出　　处：《河北中医》2011年第9期1343-1345,共3页Hebei Journal of Traditional Chinese Medicine

摘　　要：目的观察益气健脾中药联合马来酸依那普利片对慢性心力衰竭(以下简称慢性心衰)患者血清尿酸(UA)水平及心功能的影响。方法将60例慢性心衰患者随机分为2组,对照组30例予马来酸依那普利片治疗,治疗组30例在对照组治疗基础上加益气健脾中药治疗。2组均2周为1个疗程,治疗4个疗程。观察2组治疗前后UA水平、左室舒张末期内径(LVEDD)及左室射血分数(LVEF)变化情况,并统计临床疗效。结果 2组治疗后UA、LVEDD及LVEF与本组治疗前比较均明显改善(P<0.05),且2组治疗后比较差异有统计学意义(P<0.05),治疗组改善优于对照组。治疗组总有效率80.0%,对照组总有效率33.3%,2组总有效率比较差异有统计学意义(P<0.05),治疗组疗效优于对照组。结论益气健脾中药联合马来酸依那普利片能有效降低慢性心衰患者UA水平,改善心功能。Objective To investigate the effect of traditional Chinese medicine combined with enalapril on uric acid levels and cardiac function in patients with in chronic heart failure.Methods 60 patients with chronic heart failure and hyperuricemia were randomly divided into two groups.30 patients in control group were treated by enalapril.30 patients in the treatment group were treated by traditional Chinese medicine combined with enalapril.The course was 2 weeks in two groups.UA levels before and after treatment,changes of left ventricular end-diastolic diameter（LVEDD） and left ventricular ejection fraction（LVEF） were observed after four courses.Results UA,LVEDD and LVEF after treatment were significantly improved compared with those before treatment（P0.05）,and there was statistically significant difference between the two groups after treatment（P0.05）.The improvement in the treatment group was better than the control group.The total effective rate in treatment group（80.0%） was significantly higher than that in control group（33.3%,P0.05）.Conclusion Traditional Chinese medicine combined with enalapril can effectively decrease UA level in patients with chronic heart failure,and improve cardiac function.

关 键 词：心力衰竭 慢性病 高尿酸血症 尿酸 依那普利 中西医结合疗法 

分 类 号：R541.6[医药卫生—心血管疾病] R446.122[医药卫生—内科学]