色谱法和电位法在测定药物苯溴马隆离解常数中的比较  

A Comparative Study of Chromatography and pH-potentiometry for Determination of Dissociation Constants of Benzbromarone

作　　者：贾沪宁[1] 陆婷[2] 于清风[1] 倪坤仪[1] 

机构地区：[1]中国药科大学分析化学教研室,江苏南京210009 [2]中国药科大学药学院,江苏南京210009

出　　处：《化学世界》2011年第10期588-591,共4页Chemical World

摘　　要：离解常数是从分子水平深入理解一些药物的吸收、体内分布以及代谢等研究的一个重要参数。以苯溴马隆为样品,对色谱法在药物离解常数中的应用进行了考察,并与经典的电位法进行了详细的比较和分析,还对毛细管电泳法、电位滴定法进行了优化和改进。The dissociation constant constitutes important data for a thorough understanding of absorption,transport and receptor binding of some drugs at the molecular level.The pKa of benzbromarone was determined by chromatography method and compared carefully with potentionmetry method.At the same time,the determination of dissociation constant based on capillary electrophoresis and potentionmetry was optimized and improved.

关 键 词：离解常数 苯溴马隆 色谱法 pH薄层色谱 高效液相色谱 毛细管电泳 电位滴定 

分 类 号：O657.7[理学—分析化学] R917[理学—化学]