“毒损肾络”对糖尿病肾病形成的病理机制  

Pathological Mechanism for Pathogenic Toxin Impairing Kidney Collateral' in the Formation of Diabetic Nephropathy

作　　者：金明柱[1] 李敬林[1] 

机构地区：[1]辽宁中医药大学,辽宁沈阳110847

出　　处：《中华中医药学刊》2011年第11期2407-2410,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(30973778)

摘　　要：糖尿病肾病是糖尿病典型的微血管病变,主要临床病理特点是尿白蛋白排泄率(UAER)和肾小球滤过率(GER)的改变而先有出现蛋白尿,以后出现水肿,高血压,晚期出现严重肾功能衰竭。毒邪和络病学说是目前中医学术方面两大研究焦点,是多种慢性疑难病,难治病的共通病理机制,即毒邪致病的广泛性、病位的多层次性、以及作用的多维性特点与络脉分布的网络性、易滞易瘀的病理性特点相似。因此,毒损络病可导致脏腑功能失常和组织损伤并在糖尿病肾病形成也具有显著的指导意义和特色。Diabetic nephropathy is a typical microvascular disease,and the main clinical and pathological features include the changes of urinary albumin excretion rate（UAER） and glomerular filtration rate（GER）.There would be appeared proteinuria first,then edema,hypertension,and severe renal failure in the terminal period.The theories of pathogenic toxin and collateral disease are the two academic researching priorities in TCM,which are also the common pathological mechanism of a variety of chronic stubborn diseases.The features such as universality of toxins pathogenic toxin,multi-level in the location and multi-dimension in the effect,are similar to network-like distribution and pathological susceptibility to get stagnation or stasis of the collaterals.Therefore,＇pathogenic toxin impairing kidney collateral＇ could lead to visceral dysfunction and impairment of tissues,and have a significance in the formation of diabetic nephropathy.

关 键 词：毒邪 络病:糖尿病肾病 毒损肾络 

分 类 号：R259.872[医药卫生—中西医结合]