熊去氧胆酸治疗药物性肝损伤疗效观察  

Effect of ursodeoxycholic on drug-induced liver injury

作　　者：范蜀滨[1] 范蜀琦[1] 

机构地区：[1]云南省昆明市第一人民医院肝胆胰Ⅱ科,云南昆明650011

出　　处：《吉林医学》2011年第29期6112-6112,共1页Jilin Medical Journal

摘　　要：目的:观察熊去氧胆酸治疗药物性肝损伤疗效。方法:将药物性肝损伤患者102例随机分为治疗组50例,对照组52例.分别比较用药后的肝功能指标变化。结果:两组治疗后2周,谷丙转氨酶(ALT)、血清总胆红素(STB)、谷草转氨酶(AST)较治疗前均降低,但熊去氧胆酸组较对照组降低更明显(P<0.05)。结论:熊去氧胆酸治疗药物性肝损伤疗效显著。Objective To investigate the therapeutic effect of ursodeoxycholic acid on drug-induced liver injury.Method One hundred and fifty-two patients with drug-induced liver injury were divided into treatment group（50 cases） and control group（52cases） at random.Items of liver function test were investigated after treatment.Result Alanine aminotransferase（ALT）,serum total bilirubin（STB）,aspartate aminotransferase（ALT） in both group decreased significantly and was lower in treatment group（P0.05）.Conclusion Ursodeoxycholic acid is more effective than routine treatment.

关 键 词：药物性肝损伤 熊去氧胆酸 

分 类 号：R595.3[医药卫生—内科学]