普罗布考联合阿托伐他汀对冠心病患者氧化型低密度脂蛋白及其抗体的影响  

The Effect of Probucol and Atorvastatin Combination on ox-LDL and ox-LDL-Ab Level in Patients with Coronary Heart Disease

作　　者：刘小平[1] 马淑梅[2] 冯玉宝[1] 李永玲[1] 苏平[1] 王海军[1] 

机构地区：[1]内蒙古鄂尔多斯市中心医院心内科,内蒙古鄂尔多斯市017000 [2]中国医科大学附属盛京医院心内科,辽宁省沈阳市110004

出　　处：《中国动脉硬化杂志》2011年第11期923-925,932,共4页Chinese Journal of Arteriosclerosis

摘　　要：目的比较冠心病患者使用普罗布考联合阿托伐他汀与单用阿托伐他汀对氧化型低密度脂蛋白及其抗体的影响。方法将48例冠心病患者随机分为单药治疗组(阿托伐他汀20 mg/d)和联合治疗组(普罗布考1g/d+阿托伐他汀20 mg/d),分别测量两组患者服药前和服药1个月后氧化型低密度脂蛋白、氧化型低密度脂蛋白抗体和血脂水平。结果两组患者治疗后血清低密度脂蛋白、氧化型低密度脂蛋白、总胆固醇和甘油三酯水平较治疗前明显降低(P<0.01);单药治疗组氧化型低密度脂蛋白抗体水平无明显变化;联合治疗组氧化型低密度脂蛋白抗体水平明显降低(P<0.01),且低密度脂蛋白、氧化型低密度脂蛋白、总胆固醇的降低幅度大于单药治疗组(P<0.05)。结论普罗布考联合阿托伐他汀与单用阿托伐他汀均能降低冠心病患者血清氧化型低密度脂蛋白水平,但联合治疗组比单药治疗组降低更明显。单用阿托伐他汀对氧化型低密度脂蛋白抗体无明显影响,但联合普罗布考可明显降低氧化型低密度脂蛋白抗体水平。Aim To compare the effects of probucol combined with atorvastatin and atorvastatin only on serum oxidized low density lipoprotein（ox-LDL）and ox-LDL antibodies（ox-LDL-Ab） levels.Methods Forty eight patients with coronary heart disease were assigned to atorvastatin only group（20 mg/d of atorvastatin,n=22） or combined therapeutic group（20 mg/d of atorvastatin and 1.0 g/d of probucol,n=26） in a randomized manner.Serum levels of ox-LDL and ox-LDL-Ab were detected before and after treatment.Results After treated with atorvastatin only and combined therapy the levels of serum LDL,ox-LDL,TC and TG were significantly decreased（P0.01）,and those in combined therapy decreased even more markedly（P0.05）.Alone in the treatment group ox-LDL antibodies had no significant effect（P0.05）.Combined treatment group can significantly reduce the level of ox-LDL antibody（P0.01）.Conclusions Both atorvastatin alone and atorvastatin combined probucol can decrease the levels of ox-LDL in patients with coronary heart disease,and those in combined therapy decreased even more markedly.Alone in the treatment group ox-LDL antibodies had no significant effect.But combined treatment group can significantly reduce the level of ox-LDL antibody levels.

关 键 词：普罗布考 阿托伐他汀 冠心病 氧化型低密度脂蛋白 氧化型低密度脂蛋白抗体 

分 类 号：R5[医药卫生—内科学]