冠心通脉胶囊对血管内皮功能的影响  

Effect of Guanxintongmai capsule on blood vessel endothelium function

作　　者：柯于鹤[1] 赵辉[2] 陈烈[2] 雷健[1] 

机构地区：[1]武汉市第一医院心内科,武汉430022 [2]湖北中医药大学,武汉430065

出　　处：《天津中医药》2011年第5期379-380,共2页Tianjin Journal of Traditional Chinese Medicine

基　　金：武汉市卫生局资助项目(武卫[2007]43号)

摘　　要：[目的]探讨冠心通脉胶囊对冠心病患者血管内皮功能的影响及可能机制[。方法]60例冠心病患者被随机分为治疗组与对照组,各30例,治疗组在服用常规药物治疗的基础上加用冠心通脉胶囊,对照组则在常规药物治疗的基础上加用通心络胶囊,服用1个疗程后,比较两组患者血中内皮素(ET)、一氧化氮(NO)、高敏C反应蛋白(hs-CRP)的含量变化[。结果]治疗组、对照组在疗程结束后血中ET、hs-CRP含量均较治疗前明显降低(P<0.05);治疗组、对照组患者血中NO含量均较治疗前有明显升高(P<0.05)。治疗组和对照组之间无统计学差异(P>0.05)。[结论]冠心通脉胶囊可以升高患者NO,降低ET、hs-CRP,这可能是其保护血管内皮功能的机制之一。[Objective] To study the mechanism of Guanxintongmai capsule on coronary heart disease patients.[Methods] The sixty patients with angina pectoris were randomly divided into two groups： treatment group（n=30） treated with Guanxintongmai capsule and the control group（n=30） with Tongxinluo capsule for four weeks.Then we analyzed the levels of ET/NO/hs-CRP in the patients between the two groups.[Results] The levels of NO in the treatment group and the control group were improved significantly.The levels of ET and hs-CRP in the treatment group and the control group were decreased significantly.There were no significant difference between the treatment group and control group.[Conclusion] Guanxintongmai capsule can significantly increase the level of NO and decrease the level of ET and hs-CRP.This is one of mechanism of protecting blood vessel endothelium function of guanxintaomai possibly.

关 键 词：冠心病 冠心通脉胶囊 内皮功能 一氧化碳 高敏C-反应蛋白 内皮素 

分 类 号：R541.5[医药卫生—心血管疾病]