复方首乌软胶囊对D-半乳糖致亚急性衰老小鼠p16基因表达的影响  

Effects of Shouwu Soft Capsules on p16 Gene Expression of D-Galactose-induced Subacute Aging Mice

作　　者：姚毅[1] 谭喜莹[1] 王淑云[1] 朱萱萱[1] 

机构地区：[1]江苏省中医院,南京210029

出　　处：《药学与临床研究》2011年第5期411-413,共3页Pharmaceutical and Clinical Research

基　　金：江苏省中医药管理局基金项目(K2009J045-p)

摘　　要：目的:研究复方首乌软胶囊对衰老小鼠p16基因表达的影响,探讨复方首乌软胶囊的抗衰老机制。方法:用D-半乳糖建立衰老小鼠模型,以复方首乌软胶囊治疗,实时荧光定量PCR法观察小鼠脑海马p16基因的mRNA表达。结果:复方首乌软胶囊组p16基因mRNA表达降低。结论:复方首乌软胶囊能降低p16基因的表达,从而起到抗衰老作用。Objective： To study the effects of Shouwu Soft Capsules on p16 gene expression in D-galactose-induced subacute aging mice.Methods： The mice was injected with D-galactose to built the model of aging and then treated with Shouwu Soft Capsules,the mRNA expression of p16 gene in brain was observed.Results： mRNA expression of p16 gene in Shouwu Soft Capsules groups was decreased.Conclusion： Shouwu Soft Capsules can decrease the expression of p16 gene and have antiaging actions.

关 键 词：复方首乌软胶囊 衰老 P16基因表达 

分 类 号：R285.5[医药卫生—中药学] R965.1[医药卫生—中医学]