光遗传学  

Optogenetics

作　　者：林其谁[1] 

机构地区：[1]中国科学院上海生命科学研究院生物化学与细胞生物学研究所,细胞生物学国家重点实验室(筹),上海200031

出　　处：《生命科学》2011年第10期935-937,共3页Chinese Bulletin of Life Sciences

摘　　要：虽然"光遗传学"只是一种技术方法,但它在文献中正愈来愈多地被提到。光遗传学结合了重组DNA技术与光学技术,对细胞生物学的研究非常有用。它被广泛应用于活细胞内目标蛋白质的跟踪以及选择性地控制脑中某类细胞的特定的神经活动从而推动了神经科学研究的深入。近来光遗传学的应用扩展到了信号转导的研究,也开始有医学临床的应用的报道。进一步发展光遗传学无疑将推动合成生理学的研究。光遗传学被《自然-方法学》期刊评为2010年年度方法。The term ＂Optogenetics＂ has been widely used in the literature,although it is simply a technical method.Optogenetics combines recombinant DNA technology and optic technology,and is very powerful for cell biology research.It has been widely used for tracing target protein in living cell as well as selectively controlling precise neural activity patterns within subtypes of cells of the brain for in depth study of neuroscience research.Recently optogenetics has been extended to the study of signal transduction and even be explored for clinical application.Further development of optogenetics will no doubt feasible the study of synthetic physiology.Optogenetics was selected by the journal of Nature Methods as method of the year 2010.

关 键 词：光遗传学 光敏蛋白质 光激活离子通道 神经元 

分 类 号：Q784[生物学—分子生物学]