中毒性心肌损害患者TNF-a,IL-6,CRP的血清学变化及临床意义  

Change and Significance of serum TNF-a、IL-6 and CRP Levels in Patients with Myocardium Injury by Acute Poisoning

作　　者：毕玉磊 胡英华 赵彦辉 邱丽丽 马龙 冯克玉 

机构地区：[1]黑龙江省第二医院中毒科,哈尔滨150010

出　　处：《航空航天医学杂志》2011年第10期1180-1181,1269,共3页Journal of Aerospace medicine

基　　金：黑龙江省卫生厅课题(编号:2004-208)

摘　　要：目的:探讨中毒性心肌损害患者血清中TNF-a,IL-6,CRP的变化及临床意义。方法:选择急性中毒患者157例,其中合并心肌损害88例,入院第二天抽血测血清中TNF-a,IL-6,CRP的浓度。结果:中毒组非心肌损害组和心肌损害组分别与对照组比较,TNF-a,IL-6,CRP水平均升高且有显著差异(P<0.01);心肌损害组和非心肌损害组比较,两组3项指标均有显著差异(P<0.01);心肌损害组随心肌损害程度3项指标升高,其中重度分别和中度、轻度之间比较有显著差异(P<0.05)。结论:炎性因子参与了急性中毒发生和发展过程,在合并心肌损害时并进一步表达,程度与病情轻重呈相关性,即病情越重,其含量越高。Objective：To investigate the change and signific-ance of serum plasma tumor necrosis factor-a（TNF-a）、interleukin-6（IL-6）and C-reactive prtein（CRP） levels in patients with myocardium injury by acute poisoning.Methods：the serum TNF-a、IL-6 and CRP in patients with acute poisoning for 157 cases,including myocardium injury for 88 cases,were measured on the second day.Results：the TNF-a、IL-6 and CRP levels in the patients with myocardium injury（group A）and non-myocardium injury（group B）by acute poisoning were signify-cantly higher than the levels in the healthy subjects（group C）（P〈0.01）,as well as between group A and group B（P〈0.01）.myocardium injury gets worse along with deepening of poison-ing degrees.Conclusions：The cytokine play important roles in acute poisoning,especially in myocardium injury,along with deepening of poisoning degrees,they are higher.

关 键 词：中毒性心肌损害 肿瘤坏死因子-A 白细胞介素-6 C-反应蛋白 

分 类 号：R595.4[医药卫生—内科学]