重组人干扰素预防新兵急性呼吸道病毒感染的经济学分析  

ECONOMICS OF RECOMBINANT HUMAN INTERFERON TO PREVENT ACUTE VIRAL RESPIRATORY INFECTIONS IN MILITARY RECRUITS

作　　者：高璐璐[1] 陈清[1] 申玉杰[1] 李建栋[1] 郭江[1] 俞守义[1] 

机构地区：[1]南方医科大学热带医学与公共卫生学院流行病学系,广州510515

出　　处：《解放军预防医学杂志》2011年第5期336-339,共4页Journal of Preventive Medicine of Chinese People's Liberation Army

基　　金：国家"863"计划项目传染性非典型肺炎防治重大专项(No.2003AA208220)

摘　　要：目的评价重组人干扰素-α2b喷雾剂预防新兵急性呼吸道病毒感染的效果和经济效益,为军队人群寻求经济有效的预防呼吸道病毒感染策略提供参考。方法采用随机、对照、双盲的平行试验设计,以不同地区的1499名新兵为研究对象进行药物效果的评价,采用成本-效果分析(CEA)、成本-效益分析(CBA)对药物的经济学价值进行评估。结果试验组腺病毒、甲型流感病毒、乙型流感病毒、副流感病毒4种病毒急性呼吸道感染率分别下降4.1%、16.2%、12.0%、11.8%,增量成本与效果比(△C/△E)分别是3517.07、890.12、1201.67、1222.03元,效益成本比(BCR)为1.90。结论重组人干扰素-α2b对新兵急性呼吸道病毒感染不仅具有较好的预防作用,而且具有一定的经济学价值。Objective To assess the efficacy and economics of a low-dose recombinant human interferon α-2b（rIFNα-2b） nasal spray for preventing acute viral respiratory infections in military population.Methods A randomized controlled trial was performed in 1449 recruits.Cost-benefit analysis（CBA）and cost-effectiveness analysis（CEA）were carried out to assess the economics of recombinant human interferon α-2b nasal spray.Results The recombinant human interferon α-2b nasal spray had the benefits in prevention of infections caused by adenovirus,influenza A virus,influenza B virus,and parainfluenza viruses.The infection rate with the 4 viruses dcreased by 4.1%,16.2%,12.0%,and 11.8% respectively;the ratio of increased cost to effectiveness（△C/△E） was 3517.07,890.12,1201.67,and 1222.03 respectively,and the benefit-cost ratio（BCR） was 1.90.Conclusion The recombinant human interferon α-2b nasal spray was effective and economic for preventing common acute viral respiratory infections in military recruits.

关 键 词：新兵 急性呼吸道病毒感染 重组人干扰素 经济学 

分 类 号：R183.3[医药卫生—流行病学]