离子敏感型吲哚美辛眼用原位凝胶的制备与质量控制  

Preparation and Quality Control of Ion-sensitive in Situ Gel of Indometacin for Eye Use

作　　者：郭丰广[1,2] 郝吉福[1] 孝建华[2] 王建筑[1] 李菲[1] 姚欣[1] 

机构地区：[1]泰山医学院药学院,山东泰安271016 [2]泰山医学院附属医院药剂科,山东泰安271000

出　　处：《医药导报》2011年第11期1495-1498,共4页Herald of Medicine

摘　　要：目的以海藻酸钠为凝胶基质,羟丙基甲基纤维素(hydroxypropyl methyl cellulose,HPMC)为增黏剂,制备吲哚美辛离子敏感型眼用原位凝胶,并进行质量标准研究及释放度测定。方法通过对海藻酸钠与HPMC的配比研究,筛选最佳凝胶基质,制备吲哚美辛离子敏感型眼用原位凝胶;采用紫外分光光度法测定含量,用透析袋法进行体外释药实验,研究体外释药特性与机制。结果与吲哚美辛溶液相比,吲哚美辛离子敏感型眼用原位凝胶释药时间延长至8 h,释药量均>93%,而且具有良好的缓释效果。结论以海藻酸钠与HPMC制备的吲哚美辛离子敏感型眼用原位凝胶质量稳定,对眼部无刺激,且具有缓释、长效作用。Objective To study the preparation of ion-sensitive in situ gel of indomethacin for eye use by using sodium alginate as matrix and hydroxypropyl methyl cellulose（HPMC）as thickener,and investigate the quality standard and in vitro release of indomethacin gel. Methods To prepare ion-sensitive in situ gel of indomethacin for eye use and screen the best matrix of gel by comparing ratios of sodium alginate to HPMC.To determine content of indomethacin with UV spectrophotometic method and study on characteristics and mechanism of drug release by a dialysis technique. Results Compared with indomethacin solution,the release time of indomethacin in situ gel was prolonged to 8 h and the amount reached to 93%. Conclusion The in situ gel of indomethacin produced by sodium alginate and HPMC with a suitable ratio is stable,unirritated and has a slow-release and long term effect.

关 键 词：吲哚美辛 海藻酸钠 原位凝胶 离子敏感型 眼用 质量控制 

分 类 号：R971.1[医药卫生—药品] TQ460.1[医药卫生—药学]