冠脉介入术后气虚血瘀证与CYP2C19*2基因多态性的相关性研究  

Relationship between qi deficiency and blood stasis syndrome after percutaneous coronary intervention and polymorphisms of CYP2C19*2 gene

作　　者：张娅[1] 陈慧[2] 李灿东[3] 吴红霞[2] 林云钗[2] 洪丹丹[2] 王建军[2] 

机构地区：[1]福建中医药大学中西医结合研究院,福州350108 [2]福建医科大学省立临床医学院,福州350001 [3]福建中医药大学中医证研究基地,福州350108

出　　处：《中华中医药杂志》2011年第11期2521-2524,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：卫生部科学研究基金-福建省卫生教育联合攻关计划项目(No.WKJ2008-2-59)~~

摘　　要：目的:探讨冠脉介入术后(PCI)气虚血瘀证与CYP2C19*2基因多态性的相关性。方法:405例行PCI成功的冠心病患者根据术后1周是否有气虚血瘀证表型分为气虚血瘀组(167例)和非气虚血瘀组(238例),抽取外周静脉血提取DNA,采用PCR-RFLP基因分析方法检测CYP2C19*2基因多态性。结果:单因素分析显示:气虚血瘀组CYP2C19*2基因突变型(GA+AA)明显高于非气虚血瘀组(χ2=15.945,P<0.001)。多因素Logistic回归分析显示:以非气虚血瘀组为参照系,调整诸混杂危险因素后,CYP2C19*2基因突变型(GA+AA)的相对危险度(OR)为2.465,95%Cl:[1.328,4.575],P=0.004。结论:冠脉介入术后CYP2C19*2基因突变患者可能易患气虚血瘀证。Objective：To approach the relationship between qi deficiency and blood stasis syndrome after Percutaneous Coronary Intervention and polymorphisms of CYP2C19＊2 gene.Methods：405 CHD patients after receiving successful PCI were adopted in this study.Traditional Chinese Medicine（TCM） syndromes were differentiated into qi-deficiency blood-stasis type and non-qi-deficiency blood-stasis type after 7 days of standard antithrombotic therapy.All the subjects were genotyped for the polymorphisms of CYP2C19＊2 by PCR-RFLP,and the genetic variants frequencies were compared in subjects.Results：The patient genotype distribution was in Hardy-Weinberg equilibrium.The univariate analysis showed that GA＋AA was higher in qi-deficiency blood-stasis group than in non-qi-deficiency blood-stasis group（χ2=15.945,P0.001）.After adjusting for common risk factors of CHD after PCI,logistic regression analysis indicated that the odds ratios（OR） of GA＋AA（vs GG） genotype for qi deficiency and blood stasis syndrome was 2.465,95%Cl： [1.328,4.575],P=0.004,with the reference category of non-qi-deficiency blood-stasis syndrome.Conclusion：The GG＋AA genotype may be some heritable susceptibility to disease of qi deficiency and blood stasis syndrome after PCI.

关 键 词：经皮冠状动脉介入术 气虚血瘀证 CYP2C19＊2 基因多态性 

分 类 号：R541.4[医药卫生—心血管疾病]