不同产地北寒水石炮制前后药效学研究  

Comparative study on pharmacodynamic activity in vivo of North Calcitum from different origins before and after processing

作　　者：陆景坤[1] 陈朝军[1] 周昊菲[1] 李燕[1] 

机构地区：[1]内蒙古医学院药学院,呼和浩特010010

出　　处：《中华中医药杂志》2011年第11期2547-2550,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家"十一五"科技支撑计划重点项目(No.2008BAI55B02-16)~~

摘　　要：目的:比较3种产地北寒水石炮制前后主成分变化及对小鼠的胃肠功能的影响。方法:配位滴定法测定主成分硫酸钙含量;观察灌服北寒水石炮制品、生品后对正常小鼠小肠推动率、钙的吸收率以及对结扎幽门小鼠胃液分泌的影响。结果:炮制使主成分含量增加;与空白组相比,炮制前后均能有效增加小鼠肠推动率;有两种产地炮制品组小鼠对钙的吸收率显著低于另一产地的生品和炮制品组;与模型组相比,有两种产地炮制品组结扎幽门小鼠的胃液pH值显著增加,总酸度、总排酸量显著降低,其他组有一定活性,但没有显著差异。结论:不同产地寒水石炮制前后对胃肠功能的影响有所不同。Objective： To investigate the main composition and the effects of North Calcitum from different areas before and after processing on mice gastrointestinal function.Methods： The principal component（calcium sulfate） were detected by the coordination titrations.The mice were administered with the processed products and the unprocessed in order to observe the effects on the intestinal propulsion and the absorption rate and the gastric juice of pylorus-ligature mice.Results： The principal component of North Calcitum was significantly increased after processed.Compared with the control group,the processed products and the unprocessed could significantly enhance the intestinal propulsion rate of normal mice,while the absorption rate of the mice administered with the processed from two places were lower than the other processed group respectively.Compared with the model group,the acid-base scale of gastric juice of two processed from different areas groups raised remarkably,and the total acidity and the gastric acid secretory volume of both groups notably decreased.Meanwhile,others had restrainable trend to regulate gastric juice secretion and neither of them had the statistical value.Conclusion： The North Calcitum from different areas had different effects on gastrointestinal function in mice.

关 键 词：北寒水石 产地 炮制 药效 

分 类 号：R29[医药卫生—民族医学]