鳖甲煎丸抗肝癌转移的理论依据及分子机制探讨  

Research on theoretical basis and molecular mechanism of Biejiajian Wan's inhibitory effect on metastasis ability of hepatocellular carcinoma

作　　者：贺松其[1] 姚飞龙[1] 程旸[2] 李嘉璐[2] 

机构地区：[1]南方医科大学中医药学院中医基础教研室,广州510515 [2]南方医科大学第一临床学院,广州510515

出　　处：《中华中医药杂志》2011年第11期2579-2581,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然基金资助课题(No.81072934);广东省自然基金资助课题(No.9151051501000003);广东省中医药局基金资助课题(No.1050128)~~

摘　　要：转移和侵袭是肝癌的基本特征,也是影响肝癌治疗效果的重要因素。肝细胞癌的转移侵袭与Wnt/β-catenin信号通路密切相关。针对肝癌转移的病机特点,从扶正培本、解毒散结及活血化瘀等3个方面分析了鳖甲煎丸抗肝癌转移的防治原则和理论依据。在此基础上,深入探讨鳖甲煎丸干预肝细胞癌转移的作用机制和分子机制,对筛选肝细胞癌的预后指标和寻找新的治疗靶点、深化和完善肝细胞癌转移侵袭的基础理论研究具有十分重要的意义。Metastasis and invasion are not only the basic characteristics of hepatocellular carcinoma,but also important factors which influence its therapeutic effect.Metastasis and invasion of hepatocellular carcinoma are closely related with Wnt/β-catenin signal transduction pathway.Aimed at pathogenic characteristics of metastasis of hepatocellular carcinoma,we analysed the treatment principles and theoretical basis of the effect that Biejiajian Wan resisted the metastasis of hepatocellular carcinoma from three aspects： strengthening body resistance and archaeus,detoxicating and resolving a mass and promoting blood circulation.Then we investigated the mechanism of Biejiajian Wan in resisting the metastasis of hepatocellular carcinoma.This research can help select the prognostic indexes of hepatic carcinoma,find new target for cancer therapy and improve the basic theory of metastasis and invasion in hepatocellular carcinoma.

关 键 词：鳖甲煎丸 肝细胞癌 Wnt/β-连环蛋白信号通路 转移侵袭 

分 类 号：R285[医药卫生—中药学]