多囊卵巢综合征在卵母细胞发生中的影响  

Effect of polycystic ovary syndrome(PCOS) on oocyte development

作　　者：朱淑娟[1] 李威[1] 吴效科[1] 

机构地区：[1]黑龙江中医药大学附属第一医院妇产科,哈尔滨150040

出　　处：《中华中医药杂志》2011年第11期2685-2687,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：科技部国家"十一五"科技支撑计划(No.2007BAI20B015)~~

摘　　要：人卵泡发育始于始基卵泡募集到形成大量生长卵泡,随之从中选择一个发育成熟进行排卵。在生长发育过程中,复杂的内分泌和卵巢旁分泌信号通路使卵泡内激素发生变化。大量卵丘细胞—卵母细胞在这个微环境中调控卵母细胞的生长发育能力,卵母细胞的发育能力表现在完成减数分裂、受精、着床等。多囊卵巢综合征(PCOS)的甾体激素合成异常,糖、脂代谢机制受损,特征性表现为高雄激素血症、胰岛素抵抗致高胰岛素血症及不孕。除内分泌异常外,还表现为卵巢内转化生长因子-β(TGF-β)蛋白家族对卵泡发育的异常调节。Human follicle development requires the recruitment of primordial follicles into a cohort of growing follicles from which one follicle is selected to ovulate a mature oocyte.During this developmental process,complex endocrine and intraovarian paracrine signals create a changing intrafollicular hormonal.With this microenvironment,appropriate cumulus cell-oocyte signaling governs oocyte developmental competence,defined as the ability of the oocyte to complete meiosis and undergo fertilization,embryogenesis.Many of these mechanisms are perturbed in polycystic ovary syndrome（PCOS）,which is characterized by ovarian hyperandrogenism,hyperinsulinemia from insulin resistance and reduced fecundity.In addition to these endocrinopathies,pcos also is characterized by paracrine dysregulation of follicle development by intraovarian proteins of the transforming growth factor β（TGF-β） family.

关 键 词：多囊卵巢综合征 卵泡发育 卵母细胞成熟 转化生长因子-Β 

分 类 号：R711.75[医药卫生—妇产科学]