日本血吸虫病不同病程病型患者血浆D-二聚体水平研究  

Study of plasma D-dimer levels in patients with different degrees and types of schistosomiasis japonica

作　　者：周晓蓉[1] 龚新国[1] 岑丽萍[1] 王敏 廖国祥 黄希宝[1] 夏菁[1] 戴裕海[1] 

机构地区：[1]湖北省疾病预防控制中心血吸虫病防治研究所,湖北武汉430079 [2]湖北省荆州市三医院

出　　处：《中国病原生物学杂志》2011年第10期748-749,726,共3页Journal of Pathogen Biology

摘　　要：目的了解日本血吸虫病不同病程、病型患者血浆D-二聚体水平及其临床意义。方法采集慢性血吸虫病(40例)、晚期血吸虫病巨脾型(37例)、晚期血吸虫病腹水型(38例)患者及健康人(47例)血浆,采用胶乳增强免疫比浊法(ITM)检测D-二聚体含量。用t检验、Spearman相关分析及线性回归分析研究血吸虫病不同病程、病型患者血浆D-二聚体水平与年龄、性别及血吸虫病病程、病型的相关性。结果血浆D-二聚体水平与血吸虫病病程呈正相关(r=0.567,P<0.05);晚血腹水型与晚血巨脾型患者血浆D-二聚体水平的平方根差异无统计学意义(t=0.05;P>0.05)。线性回归分析性别、年龄对血浆D-二聚体水平无显著影响,病程与血浆D-二聚体水平呈正相关(r=-0.001,P>0.05)。结论血浆D-二聚体水平可作为反映血吸虫病病情严重程度的指标。Objective To detect plasma D-dimer levels in patients with different degrees and types of schistosomiasis japonica and the clinical significance of those levels.Methods Plasma D-dimer levels were detected by immunoturbidimetry（ITM） in 40 patients with chronic schistosomiasis japonica,37 patients with advanced megalosplenia,38 patients with advanced ascites,and 47 healthy individuals.A t-test,Spearman correlation analysis,and linear regression were performed to analyze data.Results Plasma D-dimer levels were positively correlated with the degree of disease,as indicated by an r of 0.567（P〈0.05）.There was no significant difference in the square root of plasma D-dimer levels for patients with advanced megalosplenia and advanced ascites.Linear regression analysis indicated that gender and age had little effect on plasma D-dimer levels,and the degree of disease was positively correlated with plasma D-dimer levels.A worse condition was associated with higher plasma D-dimer levels.Conclusion Plasma D-dimer levels can serve as an important indicator of the degree of schistosomiasis japonica.

关 键 词：血吸虫病 日本 D-二聚体 水平 

分 类 号：R532.21[医药卫生—内科学]