冠心病患者血清同型半胱氨酸及超敏C反应蛋白的检测  

The detection of serum levels of Hcy and hs-CRP in patients with coronary heart disease

作　　者：耿明霞[1] 何峰容[1] 殷少华[1] 马杰[1] 

机构地区：[1]湖北省新华医院检验科,武汉430015

出　　处：《检验医学与临床》2011年第21期2608-2609,共2页Laboratory Medicine and Clinic

摘　　要：目的探讨同型半胱氨酸（Hcy）、超敏C反应蛋白（hs-CRP）、B型脑钠肽（BNP）等心肌指标与冠心病（CHD）的关系。方法测定180例CHD患者,男115例,女65例,年龄41-75岁,平均（54.2±9.0）岁,其中心肌梗死（AMI）58例,不稳定型心绞痛（UAP）62例,稳定型心绞痛（SAP）60例;健康体检者40例,男20例,女20例,平均年龄（52.3±8.8）岁。生化常规检测心肌标志物肌钙蛋白I、肌红蛋白、Hcy、hs-CRP、BNP等相关指标。结果 CHD患者Hcy、hs-CRP、BNP及相关心肌标志物明显高于健康对照组,差异有统计学意义（P〈0.01）,而AMI组、UAP组明显高于SAP组,差异也有统计学意义（P〈0.01）。结论对CHD患者进行Hcy、hs-CRP、BNP的有效监测,将有助于了解病程,并进行有效控制。Objective To assess the relationship between coronary heart disease（CHD） and biochemical markers of myocardiac injury,such as homocysteine（Hcy）,high-sensitivity C-reactive protein（hs-CRP） and brain natriuretic peptide（BNP）.Methods The serum levels of cardiac troponin I（cTnI）,myoglobin（Myo）,Hcy,hs-CRP and BNP were detected by routine biochemistry methods.There were totally 180 patients with CHD（115 males/65 females） included.58 patients of which were defined as acute myocardial infarction（AMI）.62 cases were defined as unstable angina pectoris（UAP） and 60 cases were defined as stable angina pectoris（SAP）.40 healthy blood donors（20 males/20 females） were chosen as the controls of this study.Results Serum levels of Hcy,hs-CRP and BNP were obviously higher those in the healthy controls（P0.01）,and the AMI as well as UPA group had a higher level than that in the SAP group（P0.01）.Conclusion Our data indicate that serum levels of Hcy,hs-CRP and BNP could be used to monitor myocardial injury and the development of CHD.

关 键 词：同型半胱氨酸 超敏C反应蛋白 B型脑钠肽 冠心病 

分 类 号：R714.246[医药卫生—妇产科学]