轻中度高血压患者血压达标后动态血压及血压节律的变化特点  

Change characteristics of ambulatory blood pressure and blood pressure rhythm after blood pressure reaching standard in patients with mild or moderate hypertension

作　　者：韩楠楠[1] 王其新[1] 

机构地区：[1]青岛大学医学院附属医院急诊内科,266003

出　　处：《中国循证心血管医学杂志》2011年第4期275-277,共3页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的探讨轻中度高血压患者血压达标后动态血压及血压节律的变化特点。方法选择124名轻中度高血压患者,给予口服厄贝沙坦/氢氯噻嗪复方制剂(每片含厄贝沙坦150mg及氢氯噻嗪12.5mg)控制血压,目标血压值为<130/85mmHg(1mmHg=0.133kPa),根据血压达标情况增加药物剂量,观察时间为14～16d。记录血压达标患者治疗前后动态血压参数及血压达标所需时间。结果治疗后共70例患者血压达标,血压达标患者24h收缩压(SBP),24h舒张压(DBP),昼间平均SBP,昼间平均DBP,夜间平均SBP,夜间平均DBP及脉压在治疗前后差异均有统计学意义(P均<0.05)。治疗后血压达标患者的血压节律构成比发生变化,正常血压节律患者的比例由治疗前52.8%增加至治疗后的81.4%,治疗前后血压节律构成比的差异有统计学意义(P<0.05)。血压达标患者中血压节律正常者与血压节律异常者血压达标所需天数分别为[(7.70±2.20)dvs.(9.21±2.63)d],差异有统计学意义(P<0.05)。结论厄贝沙坦/氢氯噻嗪复方制剂降低轻中度高血压患者血压的同时,改善了血压达标患者的昼夜血压节律。Objective To explore the change characteristics of ambulatory blood pressure and blood pressure rhythm after blood pressure reaching standard in patients with mild or moderate hypertension.Methods The patients with mild or moderate hypertension（n=124） were selected and orally given the compound preparation of irbesartan／｜hydrochlorothiazide（150 mg irbesartan and 12.5 mg hydrochlorothiazide in one table） for controling blood pressure.The target blood pressure was lower than 130/85 mm Hg（1 mm Hg=0.133 kPa）.The dose of medicinal was increased according to the targeting state of blood pressure.The observation was kept on for 14／｜16 days.The parameters of ambulatory blood pressure and required time for blood pressure reaching standard were recorded in the patients after blood pressure reaching standard.Results There were 70 patients reaching standard blood pressure.The differences in 24／｜hour systolic blood pressure（SBP）,24／｜hour diastolic blood pressure（DBP）,diurnal average SBP and DBP,nocturnal average SBP and DBP,and pulse pressure were statistically significant（all P0.05） before and after treatment.The constituent radio of blood pressure rhythm had changes in the patients reaching standard blood pressure after the treatment,and the proportion of patients with normal blood pressure rhythm increased from 52.8% to 81.4% and the difference was statistically significant（P0.05）.The required days for blood pressure reaching standard in the patients with normal blood pressure rhythm were（7.70±2.20） days and in those with abnormal blood pressure rhythm were（9.21±2.63） days（P0.05）.Conclusion At the same time of improving 24／｜hour blood pressure rhythm in the patients reached standard blood pressure,the administration of compound preparation of irbesartan／｜hydrochlorothiazide can decrease blood pressure in the patients with mild or moderate hypertension.

关 键 词：高血压病 厄贝沙坦/氢氯噻嗪 动态血压监测 

分 类 号：R544.1[医药卫生—心血管疾病]