2007-2010年住院患者痰标本鲍氏不动杆菌耐药性变迁分析  

Surveillance for clinical distribution and antimicrobial resistance of Acinetobacter baummannii from 2007 to 2010

作　　者：姚彬[1,2] 张委[3] 柳爱青 汪涓[1] 

机构地区：[1]北京海淀医院医院感染管理办公室,北京100080 [2]北京海淀医院医院综合内科,北京100080 [3]北京海淀医院医院检验科,北京100080

出　　处：《中华医院感染学杂志》2011年第21期4586-4588,共3页Chinese Journal of Nosocomiology

摘　　要：目的调查近4年住院患者鲍氏不动杆菌(ABA)的分布和对抗菌药物的耐药性。方法收集医院2007年7月-2010年12月痰标本分离的651株鲍氏不动杆菌,按《全国检验技术操作规程》要求操作,采用全自动微生物分析仪进行细菌鉴定及药敏试验。结果 651株ABA对半合成青霉素、头孢菌素、碳青霉烯类、氟喹诺酮类均具有较高的耐药性,对其他酶抑制剂复合制剂亦不敏感,但对阿米卡星耐药率为3.9%～18.3%,头孢哌酮/舒巴坦耐药率为4.9%～16.1%,其他抗菌药物的耐药率均>60.0%。结论鲍氏不动杆菌的耐药形势严峻,头孢哌酮/舒巴坦、阿米卡星耐药率也呈上升趋势,应引起临床高度关注。OBJECTIVE To investigate the distribution and antimierobial resistance among clinical isolates of Acine- tobacter baurnannii（ABA）from July 2007 to Dec 2010 in Haidian hospital of Beijing. METHODS A retrospective study on clinical distribution and antimierobial resistance of 11 antibiotics to ABA was undertaken. RESULTS Totally 651 strains of ABA were detected in 3719 G strains from phlegm specimen. The drug resistances to CFS （4.9%-16.1%） and AMK （3.9%-18.3%） were the lowest, and the resistance rates to other antibiotics were more than 60.00%. CONCLUSION ABA had severe drug resistance, CFS and AMK show upward trend for drug resistence.

关 键 词：鲍氏不动杆菌 分布 耐药性 抗菌药物 

分 类 号：R378[医药卫生—病原生物学]