2010年老年科患者常见病原菌分布及耐药性分析  

Antibiotic resistance of pathogens isolated from aged people in medical department for senior cadres in 2010

作　　者：朱会英[1] 王艳[1] 张海燕[1] 徐德兴[1] 

机构地区：[1]广州军区广州总医院感染管理科,广东广州510010

出　　处：《中华医院感染学杂志》2011年第21期4600-4602,共3页Chinese Journal of Nosocomiology

摘　　要：目的了解老年科患者的病原菌分布及耐药性,为临床用药提供参考。方法对2010年1-12月老年科患者临床标本分离出的病原菌种类及药敏结果进行回顾性分析,以WHONET5.4软件进行耐药数据统计。结果共分离出病原菌1822株,革兰阳性球菌占7.4%,革兰阴性菌占76.7%,真菌占15.5%,金黄色葡萄球菌和凝固酶阴性葡萄球菌对苯唑西林耐药率分别为89.0%、84.0%,无万古霉素耐药株;革兰阴性杆菌对多种抗菌药物耐药,大肠埃希菌对喹诺酮类耐药率高达89.1%;产ESBLs的大肠埃希菌和肺炎克雷伯菌检出率分别为67.8%、55.8%,铜绿假单胞菌、鲍氏不动杆菌等呈多药耐药,对亚胺培南耐药率分别达49.6%、68.3%。结论 2010年医院老年科患者感染病原菌主要为革兰阴性杆菌,铜绿假单胞菌为主要致病菌;病原菌多药耐药现象严重,应加强病原菌培养及耐药性监测,合理选用抗菌药物,减少耐药菌株的产生。OBJECTIVE To monitor the bacterial distribution and the drug resistance among elderly patients in Medical depariment for senior cadres＇, and offer the reference for the clinical use of antibiotics therapy. METHODS From Jan 2010 to Dec 2010, the pathogen strains isolated from the elderly patients and antimicrobial susceptibility was tested by computer and analyzed by the software of ＂WHONET5. 4＂. RESULTS Of 1822 pathogen strains isolated, 7.4% were Gram-positive cocci, 76.7% were Gram-negative bacilli, and 15.5% were fungi. The percentage of Oxacillin resistance of Staphylococcus aureus and coagulase-negative Staphylococcus were 89.0% and 84.0%, respectively, no vancomycin resistant. The gram-negative bacteria were unsensitive to most of antimicrobial, The resistant rates of Escherichia coli for quinolones were 89. 1%, 67. 81% of E. coli and 55.78% of Klebsiella were detected to produce extended-spectrumβ-1actamases （ESBLs）, Pseudomonas aeruginosa and Baumannii show multidrug resistant, for imipenem were 49.6% and 68.3%, respectively. CONCLUSION The major pathogens infected the elderly patients in medical department for senior cadresr are Gram-negative bacteria, and the pathogens show the high drug resistance. The result of antimicrobial susceptibility test can guide to cure and control infection of elderly patients effectively.

关 键 词：老年患者 病原菌 耐药性 

分 类 号：R378[医药卫生—病原生物学]