光纤药物溶出度实时测定仪监测头孢呋辛酯片的溶出度  

The Process Monitoring of the Dissolution of Cefuroxime Axetil Tablets with Fiber-optic Medicine Dissolution Process Real Time Test System

作　　者：傅小英[1] 

机构地区：[1]总后勤部卫生部药品器材局,北京100842

出　　处：《解放军药学学报》2011年第5期422-424,共3页Pharmaceutical Journal of Chinese People's Liberation Army

摘　　要：目的建立考察头孢呋辛酯片溶出过程的方法,初步评价制剂质量。方法用光纤溶出度实时测定仪,以对照品法实时监测头孢呋辛酯片的溶出过程。结果各批产品均在15 min溶出85%以上,溶出过程均相似,并符合《中国药典》2010年版(二部)的规定。结论各企业内生产工艺稳定。Objective To establish a method for the evaluation of the whole process of dissolution of Cefuroxime Axetil Tablets and for preliminary assessment of their quality.Methods The release process of Cefuroxime Axetil Tablets was determined simultaneously with FODT-601 Fiber-optic Medicine Dissolution Process Real Time Test System.Results The dissolution rate of samples of each batch exceeded 85% in 15 min and accorded with the Ch.P 2010.Conclusion The technology used by each factory is stable.

关 键 词：光纤溶出度实时测定法 溶出度 头孢呋辛酯片 

分 类 号：R927.11[医药卫生—药学]