奥美沙坦联合氢氯噻嗪对原发性高血压患者血压及左心室肥厚的影响  

Influence of olmesartan combined with hydrochlorothiazide on the hypertension and left ventricular hypertophy of patients with primary hypertension

作　　者：杨政杰[1] 秦娴[1] 全文超[1] 张月军[1] 

机构地区：[1]无锡市第二人民医院心内科,江苏省无锡214002

出　　处：《中国基层医药》2011年第22期3033-3034,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的观察奥美沙坦联合氢氯噻嗪治疗原发性高血压的疗效和不良反应，并与贝那普利联合氨氯地平进行疗效对比。方法将116例原发性中度高血压患者随机分为治疗组和对照组。治疗组予以奥美沙坦、氢氯噻嗪早8：00口服治疗，持续3周；对照组予以贝那普利、氨氯地平，早8：00口服治疗，也持续3周。所有患者治疗前后均测量记录血压，治疗过程中密切观察出现的不良反应，超声观察心脏肥大情况。治疗结束后比较两组疗效和不良反应。结果两组降压疗效和抑制心脏肥大方面差异有统计学意义（均P〈0．05），且前者的不良反应较轻。结论奥美沙坦联合氢氯噻嗪治疗原发性中度高血压优于贝那普利联合氨氯地平的疗效，且能够减轻治疗中出现的不良反应。Objective To observe the. efficay and adverse reactions of olmesartan combined with hydrochlorothiazide on patients with primary moderate hypertension, compared with the therapy of benazapril associated with am- lodipine. Methods 116 primary moderate hypertension patients were randomly divided into the treatment group and control group. Patients in treatment group were treated with olmesartan combined with hydrochlorothiazide oral administration,and control group were given benazapril combined with amlodipine oral administration, which lasted for 3 weeks. Every subject was measured blood pressure before and after the drug administration and observed adverse reaction. Cardiac hypertrophy was detected by UCG. A comparison was made in effectiveness of the drug and cardiac hypertrophy between two groups. Results There was significant difference in effectiveness of two anti-hypertension therapies,and cardiac hypertrophy in the treatment group was lighter than that in control group. Conclusion The therapy of olmesartan combined with hydroehlorothiazide was more effective than that of benazapril combined with amlodipine, also more depressed cardiac hypertrophy.

关 键 词：高血压 奥美沙坦 氨氯地平 贝那普利 氢氯噻嗪 心肌肥大 

分 类 号：R544[医药卫生—心血管疾病]