无创正压通气治疗对睡眠呼吸暂停低通气综合征颈动脉粥样硬化的影响  

Continuous positive airway pressure for carotid atherosclerosis in patients with obstructive sleep apnea and hypoventilation syndrome

作　　者：牛红丽[1] 马芸[2] 马利军[2] 王海播[2] 

机构地区：[1]中国人民大学医院呼吸内科,北京市100872 [2]河南省人民医院呼吸科,郑州市450003

出　　处：《中华实用诊断与治疗杂志》2011年第11期1058-1060,共3页Journal of Chinese Practical Diagnosis and Therapy

基　　金：河南省科技攻关基金资助项目(102102310440)

摘　　要：目的探讨无创正压通气治疗阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea andhypoventilation syndrome,OSAHS)后颈动脉粥样硬化的变化。方法 OSAHS患者50例行无创正压呼吸机治疗3个月,检测治疗前、后多导睡眠监测、白细胞介素-6、高敏C反应蛋白水平及颈动脉内膜中层厚度。结果呼吸机治疗后白细胞介素-6、高敏C反应蛋白水平及颈动脉内膜中层厚度下降,但与治疗前比较差异无统计学意义(P>0.05);呼吸暂停指数及合并疾病种类较治疗前下降(P<0.05),血氧饱和度较治疗前升高(P<0.05)。结论无创正压通气治疗OSAHS可阻止并可能逆转动脉粥样硬化。Objective To investigate continuous positive airway pressure for atherosclerosis in patients with obstructive sleep apnea and hypoventilation syndrome. Methods Fifty patients with obstructive sleep apnea and hypoventilation syndrome were detected the serum levels of interleukin-6, high sensitivity C-reactive protein, polysomnography and carotid intima-media thickness before and after continuous positive airway pressure treatment. Results Interleukin-6 and high sensitivity C- reactive protein levels and carotid intima-media thickness showed the downtrend after continuous positive airway pressure treatment, but there were no significant differences compared with those before treatment（P〉0.05）. The apnea hyponea index and incidence of complications decreased, and the oxygen saturation increased after treatment, which showed significant differences compared with those before treatment （P〈0.05）. Conclusion Continuous positive airway pressure for obstructive sleep apaea and hypoventilation sydrome can prevent and inverse atherosclerosis.

关 键 词：睡眠呼吸暂停低通气综合征 炎症标志物 动脉粥样硬化 

分 类 号：R766[医药卫生—耳鼻咽喉科]