双嘧达莫对犬腹部外伤合并海水浸泡后血小板活化的影响  

Effect of dipyridamole on activation of platelets in dogs with open abdominal wound after seawater immersion

作　　者：刘小鹏[1] 尹文杰[1] 郑培浩[1] 沈建良[1] 

机构地区：[1]海军总医院血液科,北京100048

出　　处：《军医进修学院学报》2011年第11期1150-1151,1173,共3页Academic Journal of Pla Postgraduate Medical School

摘　　要：目的探讨双嘧达莫对犬腹部伤合并海水浸泡后血小板活化的影响。方法 12只犬作腹部开放伤动物模型,随机分为2组,每组6只。普通治疗组经海水浸泡后,给予一般急救处理;双嘧达莫组经海水浸泡后给予一般急救处理,同时输注双嘧达莫。检测两组血液5-HT水平、血小板聚集率。结果腹部伤犬海水浸泡后,与普通治疗组比较,双嘧达莫组血液5-HT水平更高,但血小板聚集率显著下降。结论双嘧达莫治疗腹部伤合并海水浸泡犬,可有效降低血小板聚集率,但不能降低血液5-HT水平。Objective To study the effect of dipyridamole on activation of platelets in dogs with open abdominal wound after seawater immersion.Methods Twelve dogs with open abdomen wound were randomly divided into general treatment group（n=6） and dipyridamole treatment group（n=6）.After seawater immersion,dogs in general treatment group received normal first-aid treatment while those in dipyridamole treatment group received dipyridamole infusion and normal first-aid treatment.Blood 5-hydroxytryptamine level was measured and platelet aggregation rate was detected.Results The blood 5-hydroxytryptamine level was higher while the platelet aggregation rate was lower in dipyridamole treatment group than in general treatment group.Conclusion Dipyridamole can effectively decrease the platelet aggregation rate but not the blood 5-hydroxytryptamine level in dogs with open abdominal wound after seawater immersion.

关 键 词：犬 双嘧达莫 血小板聚集率 5-羟色胺 血小板活化 

分 类 号：R9[医药卫生—药学]