抗Ro-52抗体与抗SSA抗体在自身免疫病中的检测意义  

Significance of Anti-Ro-52 kDa and SSA Antibodies in Patients with Autoimmune Diseases

作　　者：金燕萍[1] 林贵高[1] 阎超[1] 鄢盛恺[1] 

机构地区：[1]中日友好医院检验科,北京100029

出　　处：《现代检验医学杂志》2011年第5期137-138,共2页Journal of Modern Laboratory Medicine

摘　　要：目的 探讨抗Ro-52 kDa自身抗体与抗SSA抗体的关系及其在中国人群中SLE和SS等自身免疫病的诊断价值.方法 收集自身免疫病患者血清,其中SLE 50例,SS 50例,其他自身免疫病30例,50例健康者血清作为对照,用免疫印迹法检测所有标本中抗Ro-52与抗SSA抗体,同时用间接免疫荧光法检测所有标本ANA核型.结果 抗Ro-52和抗SSA抗体阳性率在SLE患者中分别为60%和64%,在SS中分别为72%和82%,在其他自身免疫病患者中分别为30%和23.33%,均高于健康对照组（6%）,经χ2检验,差异有统计学意义（P＜0.05）.结论 抗Ro-52和抗SSA抗体阳性对诊断SLE和SS有一定的临床价值,二者的确切关系还需进一步探讨.Objective To investigate the clinical correlation of anti-Ro-52 and SSA antibody and to determine the clinical diagnostic value of anti-Ro-52/SSA in Chinese patients presenting with SLE,SS and other autoimmune diseases. Methods Serum samples from 50 patients with SLE, 50 with SS and 30 other autoimmune diseases were tested for the presence of anti-Ro-52 and anti-SSA using a commercial WB kit,ANA were tested by IIF, 50 health people serum as controls. Results The positive rate of anti-Ro-52 and SSA in patients with SLE were 60~/~ and 64% respectively,patients with SS were 72% and 82% respectively,patients with other autoimmune diseases were 30% and 23.33% respectively,higher than control group （6%） ,and with Z2 inspection,the difference was statistically significant （P〈0. 05）. Conclusion High preva- lence of anti-Ro-52 and SSA is of significanee in diagnosis of SLE and SS,the relationship between the two needs to be further explored.

关 键 词：系统性红斑狼疮 舍格伦综合症 自身抗体 抗Ro-52抗体 

分 类 号：R593.2[医药卫生—内科学] R392.11[医药卫生—临床医学]