常州地区女性人乳头瘤病毒感染及基因型分析  

Analysis on the Human Papillomavirus （HPV） Genotypes Distribution Pattern in Infected Women in Changzhou Area

作　　者：戚传平[1] 许联红[1] 蒋立新[1] 王永仿 

机构地区：[1]江苏大学附属武进人民医院检验科,江苏常州213002

出　　处：《现代检验医学杂志》2011年第5期152-154,共3页Journal of Modern Laboratory Medicine

摘　　要：目的 了解江苏常州地区妇女宫颈人乳头瘤病毒（HPV）感染的分布情况,为该地区宫颈疾病防治及疫苗的投入使用提供一定的依据.方法 采用导流杂交基因芯片技术对1 016例有性生活史妇女宫颈脱落细胞进行21种HPV基因型检测.结果 在被调查的1 016例妇女中共有20种HPV亚型被检测出来.HPV感染总阳性率为27.8%,高危型检出率为25.6%,低危型为3.4%,混合型感染为6.2%.HPV感染阳性排在前5位的亚型从高到低依次为HPV16,58,52,31和68.随着宫颈疾病病变级别升高,HPV感染率呈正向增加趋势.结论 常州地区HPV亚型感染分布以高危型HPV16,58,52,31,68为主,早期筛查和控制HPV感染能有效降低宫颈癌的发病率.Objective To s：udy the distribution pattern of HPV genotypes in infected women in Changzhou area,so as to provide the evidences for the prevention of cervical diseases and the clinical application of HPV vaccines. Methods A total of 1 016 women with se：：y life were detected for 21 HPV subtypes using flow-through hybridization. Results 20 different subtypes were found in 1 016 women. HPV DNA was detected in 27.8% of all the women. The high-risk HPV was detect- ed in 25.6% ,the low-risk HPV was detected in 3.4% and 6.2% patients were infected with multiple-type HPV. The most commonly found high=risk types were HPV16,HPV58,HPV52,HPV31 and HPV68. The HPV infection rate increased a- long with the upgrade of the cervical lesions. Conclusion The subtype infection rate in Changzhou area ranked as high- risk HPV16,58,52,31 and 68. So ,early screening and controlling HPV infection could decrease effectively the morbidity of cervical cancer.

关 键 词：人乳头瘤病毒 感染率 基因型 宫颈癌 

分 类 号：R373[医药卫生—病原生物学] Q786[医药卫生—基础医学]