病原菌操控宿主固有免疫细胞以求生存的机制研究进展  

The Progress of Mechanism Study on Pathogenic Microorganism Survival by Manipulation of Innate Immune Cells

作　　者：张玲[1] 梁文章[1] 陈敏 马翠卿[1] 

机构地区：[1]河北医科大学基础医学院免疫教研室,石家庄050017 [2]华北石油疾病预防控制中心,任丘062552

出　　处：《中国细胞生物学学报》2011年第11期1284-1289,共6页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(No.30901350);河北省自然科学基金(No.C2009001091);河北省卫生厅(No.09054)资助项目~~

摘　　要：在急性感染和传统感染模式中,宿主利用固有免疫机制应对一系列病原体的入侵。然而,一些病原菌可以成功逃避、抑制或颠覆免疫检测、信号转导或有效杀伤。该文就病原菌如何操纵宿主细胞的防御功能,调节胞内杀伤、信号转导,破坏固有免疫系统受体间分子信号的交联作用,并最终使微生物在宿主体内适应性生长、持续感染等方面作一综述。The innate immune mechanisms are utilized by host to prevent a range of bacteria in acute and conserved infectious pattern. However, successful intracellular pathogens can evade, inhibit or subvert immune detection, signalling transduction or effective damages. In this review, we focus on how bacterial pathogens manipulate host-cell defence system and regulate intracellular killing or signaling, and how to disrupt the molecular signal- ing crosstalk between receptors of the innate immune system, eventually contibuting to bacterial adaptive fitness and persistent infections in the host.

关 键 词：固有免疫细胞 固有免疫 病原菌 持续感染 

分 类 号：R392.1[医药卫生—免疫学]