新型可降解生物医用镁合金JDBM的研究进展  

Research progress of new type of degradable biomedical magnesium alloys JDBM

作　　者：袁广银[1] 章晓波[1] 牛佳林[1] 陶海荣[2] 陈道运[3] 何耀华[3] 蒋垚[3] 丁文江[1] 

机构地区：[1]上海交通大学材料科学与工程学院轻合金精密成型国家工程研究中心,上海200240 [2]上海交通大学附属第三人民医院骨科,上海201900 [3]上海交通大学附属第六人民医院骨科,上海200233

出　　处：《中国有色金属学报》2011年第10期2476-2488,共13页The Chinese Journal of Nonferrous Metals

基　　金：教育部博士点资助项目(20100073110004);中国博士后科学基金资助项目(20100470030);上海市科委资助项目(10JC1407400)

摘　　要：镁合金因具有与人体骨头接近的密度和弹性模量、高比强度和比刚度、生物可降解性以及生物相容性等优点,近10年来国内外研究人员对其应用于骨内植物、骨组织工程支架和心血管支架等领域进行了广泛的研究。然而,目前大多数研究均以现有商用镁合金为对象,如含Al元素的AZ31、AZ91以及含重稀土元素的WE43等,并未考虑到作为生物材料的安全性等问题。本文作者阐述镁合金作为生物医用材料的优势、面临的挑战以及应对策略;重点介绍上海交通大学轻合金精密成型国家工程研究中心近年来围绕自行研发的新型生物医用镁合金JDBM开展的研究工作;最后展望可降解生物医用镁合金的应用前景和发展方向。Mg alloys have been extensively studied in the last decade in the fields of bone implants,bone tissue engineering scaffolds and cardiovascular stents due to their excellent properties,such as close density and elastic modulus to those of nature bone,high specific strength and rigidity,biodegradation and biocompatibility.However,most of the Mg alloys studied for biodegradable materials are aluminium-containing alloys,such as AZ31 and AZ91 and some heavy rare earth elements-containing alloys such as WE43.These alloys were originally developed for structural materials which did not consider the bio-safety as biomaterials.In this work,the advantages,challenges and strategies of the Mg alloys as biomedical materials are briefly introduced.The work on biomedical Mg alloys of the National Engineering Research Center of Light Alloy Net Forming,Shanghai Jiao Tong University,is highlighted.Finally,the application prospects and direction of the biodegradable biomedical Mg alloys are prospected.

关 键 词：可降解生物医用镁合金 骨内植物 心血管支架 生物相容性 生物降解性能 

分 类 号：R318.08[医药卫生—生物医学工程]