基于核基因组标记的群体遗传学研究中的数学分析方法  

Mathematical Analysis Methods Used in Population Genetics Studies Based on Nuclear Genome Markers

作　　者：包振民[1] 王明玲[1] 李艳[1] 张玲玲[1] 胡晓丽[1] 黄晓婷[1] 胡景杰[1] 王师[1] 

机构地区：[1]中国海洋大学海洋生命学院海洋生物遗传育种教育部重点实验室,山东青岛266003

出　　处：《中国海洋大学学报（自然科学版）》2011年第11期48-56,共9页Periodical of Ocean University of China

基　　金：国家高技术研究发展计划项目(2006AA10A408);公益性行业科研专项(nyhyzx07-047);现代农业产业技术体系建设专项资助

摘　　要：近些年来,各种数学分析方法被广泛的应用于群体遗传学的研究中。然而,对这些数学分析方法的应用缺乏统一的认识,某些研究甚至存在着误用、乱用等现象。对近些年来基于核基因组标记的群体遗传学研究中主要采用的数学分析方法进行了系统的归纳整理,明晰了它们的适用条件和范围。同时,也综述了显性分子标记中对隐性等位基因频率估算的研究进展以及常用的群体遗传学分析软件包含的主要数学分析方法,对合理应用这些参数和软件进行群体遗传学分析具有指导意义。In recent years,a variety of mathematical analysis methods have been widely used in population genetics studies.However,lack of a unified undestanding of the application of these methods has led to misuse and abuse them in some instances.In this study,we reviewed major mathematical analysis methods recently used in population genetics based on nuclear genome markers.These methods were classified and their applicable conditions and limitations were shown,which is essential to apply them correctly.Moreover,we also reviewed recent progress of estimating recessive allele frequency and major mathematical analysis methods included in popular software packages for population genetic analyses,which is instructive for researchers to make appropriate use of these methods or softwares.

关 键 词：群体 分子标记 数学分析方法 隐性等位基因频率 

分 类 号：Q347[生物学—遗传学]