老年冠心病患者血清NO及NOS含量的变化  

Content Change of Serum NO and NOS in Elderly Patients with Coronary Heart Disease

作　　者：李莉[1] 周晓钢[2] 

机构地区：[1]内蒙古工业大学医院,呼和浩特010051 [2]内蒙古医学院生物化学与分子生物学教研室,呼和浩特010051

出　　处：《保健医学研究与实践》2011年第4期14-15,19,共3页Health Medicine Research and Practice

摘　　要：目的了解一氧化氮(NO)和一氧化氮合酶(NOS)与老年冠心病的关系及其临床意义。方法选取154例老年冠心病患者,106例健康人为对照组,分别测定其血清NO和NOS含量,然后对结果进行比较分析。结果老年冠心病组、健康对照组的血清NO含量分别为(62.51±15.36)mol/L和(89.31±17.26)mol/L,NOS含量分别为(8.26±5.98)和(13.45±6.24),老年冠心病组均低于对照组(P<0.05或P<0.01)。结论老年冠心病患者的NO和NOS较健康人明显减少,这可能是冠心病的一个危险因素。Objective To have a knowledge about relations between senile coronary heart disease and nitric oxide （NO） as well as nitric oxide synthase （NOS） and the clinical significance thereof. Method 154 elderly patients with coronary heart disease were chosen for the research group and 106 healthy ones formed the control group. The NO and NOS content of the two groups were determined respectively, and the results were compared and analyzed. Results For the group with senile coronary heart disease and the healthy control group, the content of serum NO was （62.51±15.36） mol/L and （89.31±17.26）mol/L respectively while the NOS content was （8.26±5.98） and （13. 45±6.24） respectively, and each content in the group with senile coronary heart disease was lower than that in the control group （P〈0, 05 or P〈0, 01）. Conclusion The contents of NO and NOS in elderly patients with coronary heart disease are obviously lower compared with those of the healthy ones, which was probably a dangerous factor causing coronary heart disease.

关 键 词：一氯化氮 冠心病 动脉粥样硬化 老年 

分 类 号：R541.4[医药卫生—心血管疾病]