丹葛滴丸大孔树脂精制工艺  

Refining Technology of Dange Dropping Pills with Macroporous Resin

作　　者：郑雅楠[1] 吕沅珊[2] 任涛[1] 

机构地区：[1]天津药物研究院,天津300193 [2]天津市南开医院中西医结合急腹症研究所,天津300100

出　　处：《中国实验方剂学杂志》2011年第22期17-20,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:对大孔树脂富集纯化丹葛滴丸的工艺条件及参数进行优化。方法:以丹酚酸B、葛根素含量为指标,考察大孔树脂对其的吸附性能和洗脱参数。结果:最终确定纯化工艺为采用AB-8型大孔树脂,树脂用量为药材2倍,树脂径高比1∶6,流速1 BV.h-1上样,5 BV pH 4盐酸水溶液洗脱弃去,3 BV 50%乙醇洗脱收集。结论:用大孔树脂对丹葛滴丸进行精制,工艺简单可行,分离效果好,减少了纯化固形物的量,从而降低服用量。Objective：To optimize purification technical conditions and parameters of Dange dropping pills by macroporous resin.Method：Investigated adsorption property and elution parameters of macroporous resins by using the content of salvianolic acid B and puerarin as indexes.Result：Finally,purification technology was determined as follows：AB-8 was optimal resin type.Capacity of AB-8 macroporous adsorptive resin was as much as 2 times to sample load（φ∶h=1∶6）,flow rate of sample was 1 BV·h-1,5 BV amount of distilled hydrochloric acid solution（pH 4）used for eluting,and 3 BV amount of 50% ethanol as desorption solvent.Conclusion：Optimum refining process of Dange dropping pills by macroporous adsorption resin was simple and feasible with good effect of separation.It could decrease the yield of extract,and dose of drug was decreased.

关 键 词：丹葛滴丸 丹酚酸B 葛根素 大孔树脂 

分 类 号：R283.6[医药卫生—中药学]