胃舒散中重金属铋在大鼠体内药代动力学研究  

Study on Pharmacokinetic of Bismuth in Weishu San in Rat

作　　者：吴艳萍[1] 林旭楷[2] 

机构地区：[1]南方医科大学中医药学院,广州510515 [2]汕头大学医学院第二附属医院,广东汕头515041

出　　处：《中国实验方剂学杂志》2011年第22期108-110,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：广东省中医药局课题(2009269)

摘　　要：目的:通过研究胃舒散中重金属铋在大鼠血液中的分布代谢情况,为研究该物质在体内的蓄积情况提供实验依据。方法:取健康大鼠,灌服胃舒散混悬液,分别于给药前及给药后5,10,15,20,25,30,40,60,120,180,240 min尾静脉采血。用电感耦合等离子体质谱仪(ICP-MS)检测铋含量,进行分析。结果:测得数据显示铋的血药浓度在0.5 h左右达到高峰,达峰浓度在15μg.L-1左右,然后快速下降,7 h降至较低水平。铋在大鼠体内的吸收半衰期14.691 min,消除半衰期293.422 min,铋在大鼠体内的血浆药物总清除率1 571.044 L.min-1.kg-1。AUC 2 063.515μg.L-1.min-1。结论:铋在大鼠体内的药代动力学模型符合一房二室模型。Objective：To study the distribution and metabolism of bismuth in Weishu San in rat blood,providing the basis for further clinical studies.Method：Blood sample was collected at 5,10,15,20,25,30,40,60,120,180,240 min after feeding healthy rats with Weishu San suspension solution.The bismuth content detected by inductively coupled plasma mass spectrometry（ICP-MS）.Result：Measured data show that plasma concentrations of bismuth reached a peak at 0.5 h,peak concentration of 15 μg·L-1 or so,and then decreased rapidly,down to a lower level at 7 h.The absorption half-life of bismuth in rats was 14.691 min and elimination half-life was 293.422 min.The total body clearance of bismuth in rats achieve 1 571.044 L·min-1·kg-1.AUC was 2 063.515 μg·L-1·min-1.Conclusion：Pharmacokinetic model of bismuth in rat meets two-compartment model with first absorption.

关 键 词：铋 胃舒散 药代动力学 大鼠 ICP-MS 

分 类 号：R285.5[医药卫生—中药学]