支架血栓症及其中药防治研究  

Latest Research Advances of In-stent Thrombosis Control

作　　者：张海燕[1,2] 邬伟魁[1] 贺娅[1] 李芳[1] 郑琴[1] 杨明[1,3] 

机构地区：[1]江西中医学院现代中药制剂教育部重点实验室,南昌330004 [2]西南交通大学材料先进技术教育部重点实验室,成都610003 [3]成都中医药大学,成都611137

出　　处：《中国实验方剂学杂志》2011年第22期250-256,共7页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：中医药行业科研专项项目(200708006);"十一五"重大新药创制重大专项(2009ZX09103-393;2009ZX09310-005)

摘　　要：研究表明,血管内介入治疗技术较简单药物治疗效果好,和外科血管搭桥术相比创伤明显减小,已在心脑血管疾病领域得到广泛应用。从经皮冠状动脉腔内成形术、裸金属支架到药物洗脱支架,支架内再狭窄问题已控制在可接受的范围。然而,支架置入术后并发症"支架血栓症"却困扰着药物洗脱支架的发展。抗血栓治疗、选择合适的支架类型和操作技术、开发新型支架和抗血栓药物、注意冠心病二级预防是预防支架内血栓形成的关键。该文主要对支架血栓症的形成原因、机制、防治(抗血小板、抗凝、溶栓)的最新研究进展及中药在其中的潜在应用进行探讨,以期为血管药物洗脱支架血栓症的防治及中医药在其中的应用提供一定的参考。Latest research advances of in-stent thrombosis control are illustrated in this review article.Endovascular interventional treatment technology is better than simple drug therapy effect and surgical vascular bypass in cardiovascular disease field.From percutaneous coronary arterial lumen angioplasty and bare metal stents to drug-eluting stents and stent restenosis has control within acceptable limits.However,complications after stent placement,＇in-stent thrombosis＇ had plagued with drug-eluting stents development.This paper makes an overview of causes,mechanisms,prevention（antiplatelet,anticoagulant,thrombolysis） of ＇in-stent thrombosis＇ and clinical applications in recent years.It was demonstrated that some herbs have shown therapeutic effects in clinical practice and animal studies.In order to provide some references to solve the problem of stent thrombosis,the latest research progress were discussed based on the literature investigation.

关 键 词：支架血栓症 心血管药物 介入治疗 抗血小板 

分 类 号：R283.6[医药卫生—中药学]