当归对先兆流产大鼠模型流产率及血清β-HCG、血浆TXB_2含量的影响  

Effects of Angelica on Abortion Rate,Serum Level of β-HCG and Plasma Level of TXB_2 in Rats with Threatened Abortion

作　　者：万娜[1] 李朝平[1] 

机构地区：[1]甘肃中医学院,甘肃兰州730000

出　　处：《西部中医药》2011年第11期32-34,共3页Western Journal of Traditional Chinese Medicine

摘　　要：目的:探讨妇科常用药"当归"对先兆流产大鼠模型的作用机制及影响。方法:选取50只大鼠(孕6～8天),运用随机数字表随机分为5组:正常组,模型对照组,当归高、中、低剂量组,每组各10只。按照3.75 mg/kg对除正常组之外其余各组大鼠灌服米非司酮片,建立先兆流产大鼠模型。造模成功后,对各中药组灌服当归水煎剂,观察该药对先兆流产大鼠模型流产率、血清β-HCG、血浆TXB2含量的影响。结果:先兆流产大鼠模型在给予当归水煎剂灌服后,中、低剂量组大鼠流产率均低于模型对照组,有统计学意义(P<0.01);当归中、低剂量组的血清β-HCG含量高于模型对照组,有统计学意义(P<0.05);当归中、低剂量组血浆TXB2含量低于模型对照组,有统计学意义(P<0.05)。结论:①先兆流产大鼠模型在给予当归水煎液灌服后,中、低剂量组流产率明显下降。②当归可升高先兆流产大鼠模型血清β-HCG含量并可降低血浆TXB2的含量。③当归对先兆流产模型大鼠的妊娠结局无不良影响,可用于先兆流产的治疗。Objective：To explore effects and mechanism of common gynecological medicine Angelica in model rats with threatened abortion.Method：50 rats （6 to 8 days pregnant）were randomly divided into five groups： normal group, model control group,Angelica high,medium and low-dose group, each group of each 10.The rats were fed to mifepristone tablets for the establishment of rat model with threatened abortion in addition to the normal group.ARer rats model were successfully made,Chinese medicine groups were fed Angelica decoction.The abortion rate,the serum level of β-HCG and the plasma level of TXB2 in rats with threatened abortion were observed.Result：The rat model with threatened abortion were given decoction of angelica, the abortion rate in the medium and low dose groups were lower than in the control group, there was statistically significant（P〈0.01）.The rat model with threatened abortion were given decoction of angelica, the levels of serum/3-HCG in the medium and low dose groups were greater than in the control group,there was statistically significant （P〈0.05）.The rat model with threatened abortion were given decoction of angelica,the levels of plasma TXB2 in the medium and low dose groups were lower than in the control group,there was statistically significant（P〈0.05）. Conclusiorr （1）After rats model with threatened abortion received decoction of angelica, the abortion rate significantly decreased in the low and medium dose groups.（1）Angeliea can increase the serum β-HCG levels and reduce the plasma TXB2 levels for model rats with threatened abortion.（3）Angelica has no adverse effects for pregnancy outcome in rats with threatened abortion. It can be used for the treatment of threatened abortion.

关 键 词：先兆流产 当归 血清Β-HCG 血浆TXB2 

分 类 号：R285.5[医药卫生—中药学]