手术治疗对阻塞性睡眠呼吸暂停综合征儿童生长激素、胰岛素样生长因子-1的影响  被引量:3

Influence of Growth Hormone and Insulin like Factor-1 in Children with Obstructive Sleep Apnea Syndrome Treated by Surgery

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作  者:梁中敏[1] 潘祖远[1] 梁小泉[1] 刘维奇[1] 成伟[1] 李青[1] 王智勇[1] 刘艳[1] 

机构地区:[1]广东省佛山市南海区人民医院耳鼻咽喉头颈外科,广东佛山528200

出  处:《临床医学工程》2011年第11期1740-1741,共2页Clinical Medicine & Engineering

摘  要:目的探讨手术(扁桃体、腺样体切除术)治疗前后儿童阻塞性睡眠呼吸暂停综征(OSAS)生长激素(GH)及胰岛素样生长因子-1(IGF-1)的变化情况。方法 200例确诊为OSAS的患儿在清晨采静脉血测定GH及IGF-1,行扁桃体、腺样体切除术后2个月,200例患儿复查GH、IGF-1,并和正常儿童测定的GH、IGF-1进行比较分析。结果 OSAS患儿术前GH、IGF-1值明显低于正常儿童,经手术治疗后,GH、IGF-1值术后较术前明显上升,与正常儿童无明显差异。结论 OSAS患儿由于睡眠缺氧,GH、IGF-1处于正常低值。手术解决上呼吸道梗阻后,GH、IGF-1水平升至正常高值。Objective To investigate the influence on growth hormone (GH) and insulin like factor-1(IGF-1) in children with obstructive sleep apnea syndrome (OSAHS) of before and after tonsillectomy and adenoidectomy. Methods Vein blood of 200 children with OSAS was sampled early in the morning. At the mean time the serum GH and IGF-1 were examined. Then 200 cases were treated by tonsillectomy and adenoidectomy. After 2 months, the cases were examined again, compared with healthy children. Results Before surgery the cases' levels of GH and IGF-1 were lower than healthy children. After surgery, the cases' levels of GH and IGF-1 compared with healthy children were not statistically significant. Conclusion Because of anoxic sleep, levels of GH and IGF-1 in children with OSAS were very low. After surgery, secretion of GH was normal.

关 键 词:儿童 阻塞性睡眠呼吸暂停综征 生长激素 胰岛素样生长因子-1 

分 类 号:R338.63[医药卫生—人体生理学] R725.6[医药卫生—基础医学]

 

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