急性冠脉综合征心肌肌钙蛋白T与血流动力学相关性研究  

Relationship between cardiac troponin T and hemodynamics in patients with acute coronary syndrome

作　　者：洪虹[1] 高小青[1] 金雪娟[1] 刘明[1] 西雁[1] 姜红[1] 葛均波[1] 

机构地区：[1]复旦大学附属中山医院心内科,上海200032

出　　处：《国际心血管病杂志》2011年第6期397-400,共4页International Journal of Cardiovascular Disease

摘　　要：目的:探讨急性冠脉综合征(ACS)患者心肌肌钙蛋白T(cTnT)与心脏血流动力学参数的相关性。方法:选择37例ACS患者,男性32例,女性5例,年龄36～84岁。不稳定型心绞痛患者5例、非ST段抬高急性心肌梗死患者6例、ST段抬高急性心肌梗死患者26例。对所有患者进行无创心脏血流动力学检查并收集cTnT等数据。采用Spearman秩相关检验分析血液指标与无创血流动力学各检测参数间的相关性,采用多元逐步回归分析进行多因素分析。结果:经Spearman秩相关分析,cTnT水平与每搏输出量、搏指数、心输出量、血管最大扩张速度、左室射血期、电机械收缩期、收缩指数、收缩功能指数、左室舒张末期容积、左室每搏作功、左室每分作功搏功指数、房缩波幅度、主动脉顺应性及心功能指数呈负相关;经多元回归分析剔除了电机械收缩期及左室射血期。结论:ACS患者的血cTnT水平与心脏血流动力学的部分指标有相关性。Objective： To investigate the relationship between plasma cardiac troponin T （cTnT） and cardiac hemodynamics in patients with acute coronary syndrome （ACS）. Methods：We chose 37 patients with ACS （32 males and 5 females, ranging 36 and 84 years in age）, 5 cases had UAP, 6 cases NSTE-AMI and 26 cases STEMI. We did non-invasive measurement of cardiac hemodynamics and determined cTnT and other blood indicators. We used Spearman rank correlation test to assess the correlation. Multivariate analysis including blood and hemodynamic parameters was performed. Results： cTnT was negatively correlated with stroke volume, stroke volume index, cardiac output, maximum speed of artery dilatation, shrinkage index, left ventricular end diastolic volume, stroke work, cardiac work, stroke work index, extent of atrial systole wave, aorta compliance, or cardiac work index. Conclusion： Plasma cTnT was related to some parameters of cardiac hemodynamics in patients with ACS.

关 键 词：急性冠脉综合征 心肌肌钙蛋白T 心脏血流动力学 

分 类 号：R541.4[医药卫生—心血管疾病]