复方苯佐卡因凝胶对试验性牙痛模型的影响  

Effects of Benzocaine compound gel on experimental toothache

作　　者：韦宝伟[1] 刘布鸣[1] 陈力力[1] 刘元[1] 姚树汉[1] 

机构地区：[1]广西中医药研究院,南宁530022

出　　处：《国际口腔医学杂志》2011年第6期641-642,645,共3页International Journal of Stomatology

摘　　要：目的对比仿制药复方苯佐卡因凝胶与其被仿制品Orajel Mouth-Aid(OMA)的镇痛作用。方法采用电刺激家兔牙髓法和光电刺激大鼠尾巴法。结果局部给药后,复方苯佐卡因凝胶和OMA均能提高动物痛阈,有良好的镇痛作用且具有剂量依赖性。结论复方苯佐卡因凝胶和OMA均有镇痛作用且作用强度相当,可用于牙痛的治疗。Objective To compare analgesic efficacy of the copied Benzocaine compound gel and its original product Orajel Mouth-Aid,an over the counter drug product made in USA.Methods Pain thresholds in dental pulp of rabbits,and in tail flick of rat model were used.Results By topical application,these two products exhibited dose-dependent analgesic actions in rabbits and rats.Conclusion These two products have analgesic efficacy with similar potency,and they are good for toothache.

关 键 词：苯佐卡因 镇痛作用 家兔 大鼠 

分 类 号：R96[医药卫生—药理学]