遍在蛋白-蛋白连接酶对骨形态发生蛋白/Smad通路的调节  

The mechanism of ubiquitin-protein ligating enzyme regulate bone morphogenetic protein signal transduction

作　　者：苏琼[1] 林正梅[1] 

机构地区：[1]中山大学光华口腔医学院.附属口腔医院牙体牙髓病科,广州510055

出　　处：《国际口腔医学杂志》2011年第6期684-687,共4页International Journal of Stomatology

摘　　要：Smad通路是转化生长因子(TGF)-β超家族包括骨形态发生蛋白(BMP)信号转导的经典通路。Smad复合物的积聚导致其基因转录的过度活化,因此Smad的降解对Smad通路的调控至关重要。遍在蛋白-蛋白水解酶复合体通路降解Smad,对调控TGF-β信号转导发挥重要的调节作用。遍在蛋白-蛋白连接酶(Smurf)作为这一系统的核心,参与调控BMP和TGF-β两个家族的分子信号转导过程。本文就TGF-β/Smad通路、遍在蛋白酶体途径、遍在蛋白-蛋白连接酶Smurf家族及其结构、遍在蛋白-蛋白连接酶Smurf-1对Smad信号通路的调节等研究进展作一综述。Smad pathway is the classic pathway of transforming growth factor（TGF）-β superfamily,including bone morphogenetic protein（BMP） signal transduction.The accumulation of Smad complexes will lead to the excessive activation of gene transcription.Therefore,the degradation of Smad is essential to the regulation of Smad pathway.The ubiquitin proteasome pathway degrades Smad proteins,which play an important role in the regulation of TGF-β family signaling.As the core of the system,Smad ubiquitin regulatory factor are HECT-type ubiquitin-protein ligating enzyme that regulate TGF-β and BMP signaling.In the nucleus,according to related literatures and combined with the latest research advances,we review that the discovery and composition of Smurf-1 and its mechanisms in regulating BMP signaling.

关 键 词：遍在蛋白-蛋白酶体降解系统 遍在蛋白-蛋白连接酶 Smad遍在蛋白调节因子 骨形态发生蛋白 

分 类 号：R341[医药卫生—基础医学]