坎地沙坦西酯与硝苯地平治疗糖尿病肾病合并高血压的临床对比研究  

CLINICAL COMPARISON ON THE CANDESARTAN CILEXETIL AND NIFEDIPINE IN TREATMENT WITH DIABETIC NEPHROPATHY WITH HYPERTENSION

作　　者：彭保康[1] 

机构地区：[1]湖北省十堰市东风汽车公司茅箭医院心肾内科,十堰442000

出　　处：《现代预防医学》2011年第22期4762-4763,4765,共3页Modern Preventive Medicine

摘　　要：[目的]比较观察坎地沙坦西酯与硝苯地平治疗糖尿病肾病合并高血压的临床疗效。[方法]2009年12月～2010年12月,102例糖尿病肾病合并高血压患者随机分为坎地沙坦西酯组和硝苯地平组,每组51例,比较观察两组治疗前后血压和血尿素氮(BUN)、肌酐(Cr)水平变化。[结果]两组治疗后SBP、DBP明显降低,与治疗前比较差异均有统计学意义(P﹤0.05);两组治疗后SBP、DBP水平比较,差异无统计学意义(P﹥0.05)。坎地沙坦西酯组治疗后BUN及Cr水平明显降低,与治疗前比较差异有统计学意义(P﹤0.05);坎地沙坦西酯组治疗后BUN及Cr水平明显低于同期硝苯地平组(P﹤0.05),而硝苯地平组治疗前后BUN及Cr水平比较,差异无统计学意义(P﹥0.05)。[结论]坎地沙坦西酯与硝苯地平治疗糖尿病肾病合并高血压患者,均有明显的降压效果,但坎地沙坦西酯具有更好地保护肾脏作用,值得临床推广应用。[Objective]To compare the clinical effects of andesartan cilexetil and nifedipine in treatment with diabetic nephropathy with hypertension.[Methods]From December 2009 to December 2010,102 cases of diabetic nephropathy with hypertension patients were randomly separated into candesartan cilexetil group and nifedipine group,and each group had 51 cases.The observation group was treated with rosuvastatin at basis of normal therapy.The blood pressure and BUN,Cr before and after treatment were observed.[Results]Compared with pre-treatment,the levels of SBP and DBP were significantly decreased（P﹤0.05）in both two groups.There was no significant difference in the levels of SBP and DBP after treatment between both groups（P﹥0.05）.Compared with pre-treatment,the levels of BUN and Cr were significantly decreased（P﹤0.05）in candesartan cilexetil group.The levels of BUN and Cr in candesartan cilexetil group were significantly lower than those in nifedipine group（P﹤0.05）,while there was no significant difference before and after treatment in nifedipine group（P﹥0.05）.[Conclusion]Both candesartan cilexetil and nifedipine in treatment with diabetic nephropathy with hypertension can low blood pressure,but candesartan cilexetil can protect kidney function,which can be applied in clinic.

关 键 词：坎地沙坦西酯 硝苯地平 糖尿病肾病 高血压 

分 类 号：R587.1[医药卫生—内分泌]